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Pleural Disease: Malignant and Benign Pleural Effusions

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Abstract

Pleural effusion is a common problem in intensive care unit (ICU) patients. Proper diagnosis involves three steps: confirmation of the effusion with imaging studies, classification as transudates or exudates and identifying the underlying cause. Imaging studies such as chest X-ray, ultrasound, and CT scan are useful to confirm the diagnosis and may also suggest the underlying cause. Ultrasound is particularly helpful in the ICU setting due to its portability and ability to characterize the effusion and guide pleural procedures. If an effusion is clinically significant or the diagnosis is unknown, then drainage and fluid analysis are essential. Mechanical ventilation is not associated with increased complications of pleural drainage and can be safely performed if indicated. Drainage also has a therapeutic objective, and it is mandatory and urgent if an infection is suspected but also indicated in patients with large effusions, a noncompliant chest wall, or severe respiratory failure requiring higher positive end-expiratory pressures (PEEP). In patients with a suspected malignant effusion, effusion will recur, and a definitive treatment may be considered if the patient survives the ICU.

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References

  1. American Thoracic Society. Management of malignant pleural effusions. Am J Respir Crit Care. 2000;162: 1987–2001.

    Article  Google Scholar 

  2. Ault MJ, Rosen BT, Scher J, Feinglass J, Barsuk JH. Thoracentesis outcomes: a 12-year experience. Thorax. 2015;70(2):127–32.

    Article  Google Scholar 

  3. Bintcliffe OJ, Lee GY, Rahman NM, Maskell NA. The management of benign non-infective pleural effusions. European respiratory review: an official journal of the European respiratory. Society. 2016;25(141):303–16.

    Google Scholar 

  4. Broaddus VC, Wiener-Kronish JP, Staub NC. Clearance of lung edema into the pleural space of volume loaded anesthetized sheep. J Appl Physiol. 1990;68(6): 2623–30.

    Article  CAS  Google Scholar 

  5. Clive AO, Kahan BC, Hooper CE, Bhatnagar R, Morley AJ, Zahan-Evans N, et al. Predicting survival in malignant pleural effusion: development and validation of the LENT prognostic score. Thorax. 2014;69(12):1098–104.

    Article  Google Scholar 

  6. Clive A, Jones H, Bhatnagar R, Preston N, Maskell N. Interventions for the management of malignant pleural effusions: a network meta-analysis. Cochrane Database Syst Rev. 2016;8:CD010529.

    Google Scholar 

  7. Corcoran JP, Psallidas I, Wrightson JM, Hallifax RJ, Rahman NM. Pleural procedural complications: prevention and management. J Thorac Dis. 2015;7(6):1058–67.

    PubMed  PubMed Central  Google Scholar 

  8. DeBiasi EM, Pisani MA, Murphy TE, Araujo K, Kookoolis A, Argento AC, et al. Mortality among patients with pleural effusion undergoing thoracentesis. Eur Respir J. 2015;46(2):495–502.

    Article  Google Scholar 

  9. Fartoukh M, Azoulay E, Galliot R, Le Gall JR, Baud F, Chevret S, et al. Clinically documented pleural effusions in medical ICU patients: how useful is routine thoracentesis? Chest. 2002;121(1):178–84.

    Article  Google Scholar 

  10. Gammie JS, Banks MC, Fuhrman CR, Pham SM, Griffith B, Keenan RJ, et al. The pigtail catheter for pleural drainage: a less invasive alternative to tube Thoracostomy. J Soc Laparoendosc Surg. 1999;3(1): 57–61.

    CAS  Google Scholar 

  11. Gervais DA, Petersein A, Lee MJ, Hahn PF, Saini S, Mueller PR. US-guided thoracentesis: requirement for postprocedure chest radiography in patients who receive mechanical ventilation versus patients who breathe spontaneously. Radiology. 1997;204(2):503–6.

    Article  CAS  Google Scholar 

  12. Godwin JE, Sahn SA. Thoracentesis: a safe procedure in mechanically ventilated patients. Ann Intern Med. 1990;113(10):800–2.

    Article  CAS  Google Scholar 

  13. Goligher EC, Leis JA, Fowler RA, Pinto R, Adhikari NK, Ferguson ND. Utility and safety of draining pleural effusions in mechanically ventilated patients: a systematic review and meta-analysis. Crit Care (London). 2011;15(1):1.

    Article  Google Scholar 

  14. Goligher EC, Ferguson ND. Utility of draining pleural effusions in mechanically ventilated patients. Curr Opin Pulm Med. 2012;18(4):359–65.

    Article  Google Scholar 

  15. Gordon CE, Feller-Kopman D, Balk EM, et al. Pneumothorax following thoracentesis: a systematic review and meta-analysis. Arch Intern Med. 2010;170:332–9.

    Article  Google Scholar 

  16. Hallifax RJ, Corcoran JP, Ahmed A, et al. Physician-based ultrasound-guided biopsy for diagnosing pleural disease. Chest. 2014;146:1001–6.

    Article  Google Scholar 

  17. Hallifax RJ, Psallidas I, Rahman NM. Chest drain size: the debate continues. Curr Pulmonol Rep. 2017;6(1):26–9.

    Article  Google Scholar 

  18. Hooper C, Lee YC, Maskell N, BTS Pleural Guideline Group. Investigation of a unilateral pleural effusion in adults: British Thoracic Society pleural disease guideline 2010. Thorax. 2010;65(Suppl 2):ii4–17.

    Article  Google Scholar 

  19. Krell WS, Rodarte JR. Effects of acute pleural effusion on respiratory system mechanics in dogs. J Appl Physiol. 1985;59:1458–63.

    Article  CAS  Google Scholar 

  20. Lai-Fook SJ. Pleural mechanics and fluid exchange. Physiol Rev. 2004;84(2):385–410.

    Article  CAS  Google Scholar 

  21. Lichtenstein D, Goldstein I, Mourgeon E, Cluzel P, Grenier P, Rouby J-J. Comparative diagnostic performances of auscultation, chest radiography, and lung ultrasonography in acute respiratory distress syndrome. Anesthesiology. 2004;100(1):9–15.

    Article  Google Scholar 

  22. Light RW. Pleural effusion. N Engl J Med. 2002;346(25):1971–7.

    Article  Google Scholar 

  23. Mattison LE, Coppage L, Alderman DF, Herlong JO, Sahn SA. Pleural effusions in the medical ICU: prevalence, causes, and clinical implications. Chest. 1997;111(4):1018–23.

    Article  CAS  Google Scholar 

  24. Mayo PH, Goltz HR, Tafreshi M, Doelken P. Safety of ultrasound-guided thoracentesis in patients receiving mechanical ventilation. Chest. 2004;125(3):1059–62.

    Article  Google Scholar 

  25. Miserocchi G. Physiology and pathophysiology of pleural fluid turnover. Eur Respir J. 1997;10:219–25.

    Article  CAS  Google Scholar 

  26. Miserocchi G, D’Angelo E, Agostoni E. Topography of pleural surface pressure after pneumo- or hydrothorax. J Appl Physiol. 1972;32:296–303.

    Article  CAS  Google Scholar 

  27. Noppen M, De Waele M, Li R, Gucht KV, D’Haese J, Gerlo E, Vincken W. Volume and cellular content of normal pleural fluid in humans examined by pleural lavage. Am J Respir Crit Care Med. 2000;162(3 Pt 1):1023–6.

    Article  CAS  Google Scholar 

  28. Oakes DD, Wilson RE, Malposition of a subclavian line. Resultant pleural effusions, interstitial pulmonary edema, and chest wall abscess during total parenteral nutrition. JAMA. 1975;233(6):532–3.

    Article  CAS  Google Scholar 

  29. Pannu J, DePew ZS, Mullon JJ, Daniels CE, Hagen CE, Maldonado F. Impact of pleural manometry on the development of chest discomfort during thoracentesis: a symptom-based study. J Bronchol Interv Pulmonol. 2014;21(4):306–13.

    Article  Google Scholar 

  30. Patil M, Dhillon SS, Attwood K, Saoud M, Alraiyes AH, Harris K. The management of benign pleural effusions using indwelling pleural catheters – a systematic review and meta-analysis. Chest. 2016;150:582A.

    Article  Google Scholar 

  31. Porcel JM, Azzopardi M, Koegelenberg CF, Maldonado F, Rahman NM, Lee YC. The diagnosis of pleural effusions. Expert Rev Respir Med. 2015;9(6):801–15.

    Article  CAS  Google Scholar 

  32. Qureshi NR, Rahman NM, Gleeson FV. Thoracic ultrasound in the diagnosis of malignant pleural effusion. Thorax. 2009;64(2):139–43.

    Article  CAS  Google Scholar 

  33. Rahman NM, Maskell NA, Davies CW, Hedley EL, Nunn AJ, Gleeson FV, et al. The relationship between chest tube size and clinical outcome in pleural infection. Chest. 2010;137(3):536–43.

    Article  Google Scholar 

  34. Raptopoulos V, Davis LM, Lee G, Umali C, Lew R, Irwin RS. Factors affecting the development of pneumothorax associated with thoracentesis. AJR Am J Roentgenol. 1991;156(5):917–20.

    Article  CAS  Google Scholar 

  35. Romero-Candeira S, Fernández C, Martín C, Sánchez-Paya J, Hernández L. Influence of diuretics on the concentration of proteins and other components of pleural transudates in patients with heart failure. Am J Med. 2001;110(9):681–6.

    Article  CAS  Google Scholar 

  36. Soni NJ, Franco R, Velez MI, Schnobrich D, Dancel R, Restrepo MI, et al. Ultrasound in the diagnosis and management of pleural effusions. J Hosp Med. 2015;10(12):811–6.

    Article  Google Scholar 

  37. Stokes LS. Percutaneous Management of Malignant Fluid Collections. Semin Interv Radiol. 2007;24(4): 398–408.

    Article  Google Scholar 

  38. Strange C. Pleural complications in the intensive care unit. Clin Chest Med. 1999;20:317–27.

    Article  CAS  Google Scholar 

  39. Traill ZC, Davies RJ, Gleeson FV. Thoracic computed tomography in patients with suspected malignant pleural effusions. Clin Radiol. 2001;56(3):193–6.

    Article  CAS  Google Scholar 

  40. Walden AP, Garrard CS, Salmon J. Sustained effects of thoracocentesis on oxygenation in mechanically ventilated patients. Respirology. 2010;15(6):986–92.

    Article  Google Scholar 

  41. Walden AP, Jones QC, Matsa R, Wise MP. Pleural effusions on the intensive care unit; hidden morbidity with therapeutic potential. Respirology. 2013;18(2): 246–54.

    Article  Google Scholar 

  42. Wang NS. Anatomy of the pleura. Clin Chest Med. 1998;19:229–40.

    Article  CAS  Google Scholar 

  43. Wilcox ME, Chong CA, Stanbrook MB, Tricco AC, Wong C, Straus SE. Does this patient have an exudative pleural effusion? The rational clinical examination systematic review. JAMA. 2014;311(23):2422–31.

    Article  Google Scholar 

  44. Yousefifard M, Baikpour M, Ghelichkhani P, Asady H, Shahsavari Nia K, Moghadas Jafari A, et al. Screening performance characteristic of ultrasonography and radiography in detection of pleural effusion; a meta-analysis. Emergency. 2016;4(1):1–10.

    PubMed  PubMed Central  Google Scholar 

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Correspondence to Macarena R. Vial .

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Landaeta, M.F., Vial, M.R. (2020). Pleural Disease: Malignant and Benign Pleural Effusions. In: Nates, J., Price, K. (eds) Oncologic Critical Care. Springer, Cham. https://doi.org/10.1007/978-3-319-74588-6_62

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  • DOI: https://doi.org/10.1007/978-3-319-74588-6_62

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-74587-9

  • Online ISBN: 978-3-319-74588-6

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