Abstract
Methods of preparation of nanoparticles of porous silicon are described, including photoluminescent formulations. Key factors discussed include control of pore size and porosity, control of nanoparticle size and size distribution, control of physical properties including degradation rates, and increasing the yield of preparations. Nanoparticles synthesized from electrochemically etched silicon wafers, from stain-etched particles, and from silicas subjected to chemical reduction are discussed.
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References
Aptekar JW, Cassidy MC, Johnson AC, Barton RA, Lee M, Ogier AC, Vo C, Anahtar MN, Ren Y, Bhatia SN et al (2009) Silicon nanoparticles as hyperpolarized magnetic resonance imaging agents. ACS Nano 3:4003–4008
Bao Z, Weatherspoon MR, Shian S, Cai Y, Graham PD, Allan SM, Ahmad G, Dickerson MB, Church BC, Kang Z et al (2007) Chemical reduction of three-dimensional silica micro-assemblies into microporous silicon replicas. Nature 446:172–175
Batchelor L, Loni A, Canham LT, Hasan M, Coffer JL (2012) Manufacture of mesoporous silicon from living plants and agricultural waste: an environmentally friendly and scalable process. Silicon 4:259–266
Bimbo LM, Sarparanta M, Santos HLA, Airaksinen AJ, Kila EM, Laaksonen T, Peltonen L, Lehto V-P, Hirvonen J, Salonen J (2010) Biocompatibility of thermally hydrocarbonized porous silicon nanoparticles and their biodistribution in rats. ACS Nano 4:3023–3032
Bley RA, Kauzlarich SM, Davis JE, Lee HWH (1996) Characterization of silicon nanoparticles prepared from porous silicon. Chem Mater 8:1881–1888
Brigger I, Dubernet C, Couvreur P (2002) Nanoparticles in cancer therapy and diagnosis. Adv Drug Deliv Rev 54:631–651
Bromley A (2000) Theranostics: the influence of diagnostics on pharmaceutical therapy. P.J.B. Publications, Richmond
Canham LT (2007) Nanoscale semiconducting silicon as a nutritional food additive. Nanotechnology 18:185704
Canham LT (2014) Porous silicon for medical use: from conception to clinical use. In: Santos HA (ed) Porous silicon for biomedical applications. Woodhead Publication, Philadelphia, pp 3–20
Chen W, Fan ZL, Dhanabalan A, Chen CH, Wang CL (2011) Mesoporous silicon anodes prepared by magnesiothermic reduction for lithium ion batteries. J Electrochem Soc 158:A1055–A1059
Cheng X, Lowe SB, Ciampi S, Magenau A, Gaus K, Reece PJ, Gooding JJ (2014) Versatile “Click chemistry” approach to functionalizing silicon quantum dots: applications toward fluorescent cellular imaging. Langmuir 30:5209–5216
Chiappini C, Tasciotti E, Fakhoury JR, Fine D, Pullan L, Wang YC, Fu LF, Liu XW, Ferrari M (2010) Tailored porous silicon microparticles: fabrication and properties. ChemPhysChem 11:1029–1035
Choi J, Wang NS, Reipa V (2007) Photoassisted tuning of silicon nanocrystal photoluminescence. Langmuir 23:3388–3394
Choi J, Zhang Q, Reipa V, Wang NS, Stratmeyer ME, Hitchins VM, Goering PL (2009) Comparison of cytotoxic and inflammatory responses of photoluminescent silicon nanoparticles with silicon micron-sized particles in RAW 264.7 macrophages. J Appl Toxicol 29:52–60
Clement D, Diener J, Gross E, Kunzner N, Timoshenko VY, Kovalev D (2005) Highly explosive nanosilicon-based composite materials. Phys Status Solidi A 202:1357–1364
Currano LJ, Churaman WA (2009) Energetic nanoporous silicon devices. J Microelectromech Syst 18:799–807
Dementyev AE, Cory DG, Ramanathan C (2008) Dynamic nuclear polarization in silicon microparticles. Phys Rev Lett 100:127601
Derfus AM, Chan WCW, Bhatia SN (2004) Probing the cytotoxicity of semiconductor quantum dots. Nano Lett 4:11–18
Erogbogbo F, Yong KT, Roy I, Xu GX, Prasad PN, Swihart MT (2008) Biocompatible luminescent silicon quantum dots for imaging of cancer cells. ACS Nano 2:873–878
Erogbogbo F, Chang CW, May JL, Liu LW, Kumar R, Law WC, Ding H, Yong KT, Roy I, Sheshadri M et al (2012) Bioconjugation of luminescent silicon quantum dots to gadolinium ions for bioimaging applications. Nanoscale 4:5483–5489
Ferrati S, Mack A, Chiappini C, Liu XW, Bean AJ, Ferrari M, Serda RE (2010) Intracellular trafficking of silicon particles and logic-embedded vectors. Nanoscale 2:1512–1520
Foll H, Carstensen J, Ossei-Wusu E, Cojocaru A, Quiroga-Gonzalez E, Neumann G (2011) Optimized Cu-contacted Si nanowire anodes for Li ion batteries made in a production near process. J Electrochem Soc 158:A580–A584
Godin B, Chiappini C, Srinivasan S, Alexander JF, Yokoi K, Ferrari M, Decuzzi P, Liu X (2012) Discoidal porous silicon particles: fabrication and biodistribution in breast cancer bearing mice. Adv Funct Mater 22:4225–4235
Gongalsky MB, Kargina YV, Osminkina LA, Perepukhov AM, Gulyaev MV, Vasiliev AN, Pirogov YA, Maximychev AV, Timoshenko VY (2015) Porous silicon nanoparticles as biocompatible contrast agents for magnetic resonance imaging. Appl Phys Lett 107:233702
Gongalsky MB, Osminkina LA, Pereira A, Manankov AA, Fedorenko AA, Vasiliev AN, Solovyev VV, Kudryavtsev AA, Sentis M, Kabashin AV et al (2016) Laser-synthesized oxide-passivated bright Si quantum dots for bioimaging. Sci Rep 6:24732
Granitzer P, Rumpf K, Tian Y, Akkaraju G, Coffer J, Poelt P, Reissner M (2013) Fe3O4-nanoparticles within porous silicon: magnetic and cytotoxicity characterization. Appl Phys Lett 102:193110
Gu L, Park J-H, Duong KH, Ruoslahti E, Sailor MJ (2010) Magnetic luminescent porous silicon microparticles for localized delivery of molecular drug payloads. Small 6:2546–2552
Gu L, Ruff LE, Qin Z, Corr M, Hedrick SM, Sailor MJ (2012) Multivalent porous silicon nanoparticles enhance the immune activation potency of agonistic CD40 antibody. Adv Mater 24:3981–3987
Gu L, Hall DJ, Qin Z, Anglin E, Joo J, Mooney DJ, Howell SB, Sailor MJ (2013) In vivo time-gated fluorescence imaging with biodegradable luminescent porous silicon nanoparticles. Nat Commun 4:2326
Guo MY, Zou XQ, Ren H, Muhammad F, Huang CX, Qiu SL, Zhu GS (2011) Fabrication of high surface area mesoporous silicon via magnesiothermic reduction for drug delivery. Microporous Mesoporous Mat 142:194–201
Heinrich JL, Curtis CL, Credo GM, Kavanagh KL, Sailor MJ (1992) Luminescent colloidal Si suspensions from porous Si. Science 255:66–68
Henstock JR, Canham LT, Anderson SI (2015) Silicon: the evolution of its use in biomaterials. Acta Biomater 11:17–26
Hessel CM, Henderson EJ, Veinot JGC (2006) Hydrogen silsesquioxane: a molecular precursor for nanocrystalline Si-SiO(2) composites and freestanding hydride-surface-terminated silicon nanoparticles. Chem Mater 18:6139–6146
Hessel CM, Reid D, Panthani MG, Rasch MR, Goodfellow BW, Wei J, Fujii H, Akhavan V, Korgel BA (2012) Synthesis of ligand-stabilized silicon nanocrystals with size-dependent photoluminescence spanning visible to near-infrared wavelengths. Chem Mater 24:393–401
Joo J, Cruz JF, Vijayakumar S, Grondek J, Sailor MJ (2014) Photoluminescent porous Si/SiO2 core/shell nanoparticles prepared by Borate Oxidation. Adv Funct Mater 24:5688–5694
Joo J, Liu X, Kotamraju VR, Ruoslahti E, Nam Y, Sailor MJ (2015) Gated luminescence imaging of silicon nanoparticles. ACS Nano 9:6233–6241
Kinsella JM, Ananda S, Andrew JS, Grondek JF, Chien M-P, Scadeng M, Gianneschi NC, Ruoslahti E, Sailor MJ (2011) Enhanced magnetic resonance contrast of Fe3O4 nanoparticles trapped in a porous silicon nanoparticle host. Adv Mater 23:H248–H253
Kovalev D, Timoshenko VY, Künzner N, Gross E, Koch F (2001) Strong explosive interaction of hydrogenated porous silicon with oxygen at cryogenic temperatures. Phys Rev Lett 87:68301–68304
Li XG, He YQ, Talukdar SS, Swihart MT (2003) Process for preparing macroscopic quantities of brightly photoluminescent silicon nanoparticles with emission spanning the visible spectrum. Langmuir 19:8490–8496
Li YY, Kollengode VS, Sailor MJ (2005) Porous silicon/polymer nanocomposite photonic crystals by microdroplet patterning. Adv Mater 17:1249–1251
Limaye S, Subramanian S, Goller B, Diener J, Kovalev D (2007) Scalable synthesis route for silicon nanocrystal assemblies. Phys Status Solidi A 204:1297–1301
Low SP, Voelcker NH, Canham LT, Williams KA (2009) The biocompatibility of porous silicon in tissues of the eye. Biomaterials 30:2873–2880
Meade SO, Sailor MJ (2007) Microfabrication of freestanding porous silicon particles containing spectral barcodes. Phys Status Solidi Rapid Res Lett 1:R71–R73
Moghimi SM, Hunter AC, Murray JC (2001) Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol Rev 53:283–318
Mukherjee P, Whitehead MA, Senter RA, Fan DM, Coffer JL, Canham LT (2006) Biorelevant mesoporous silicon/polymer composites: directed assembly, disassembly, and controlled release. Biomed Microdevices 8:9–15
Nissinen T, Ikonen T, Lama M, Riikonen J, Lehto VP (2016) Improved production efficiency of mesoporous silicon nanoparticles by pulsed electrochemical etching. Powder Technol 288:360–365
Park J-H, Gu L, Maltzahn Gv, Ruoslahti E, Bhatia SN, Sailor MJ (2009) Biodegradable luminescent porous silicon nanoparticles for in vivo applications. Nat Mater 8:331–336
Petrova-Koch V, Muschik T, Kux A, Meyer BK, Koch F, Lehmann V (1992) Rapid thermal oxidized porous Si- the superior photoluminescent Si. Appl Phys Lett 61:943–945
Pettigrew KA, Liu Q, Power PP, Kauzlarich SM (2003) Solution synthesis of alkyl- and alkyl/alkoxy-capped silicon nanoparticles via oxidation of Mg2Si. Chem Mater 15:4005–4011
Qin Z, Joo J, Gu L, Sailor MJ (2014) Size control of porous silicon nanoparticles by electrochemical perforation etching. Part Part Syst Charact 31:252–256
Ruoslahti E, Bhatia SN, Sailor MJ (2010) Targeting of drugs and nanoparticles to tumors. J Cell Biol 188:759–768
Russo L, Colangelo F, Cioffi R, Rea I, De Stefano L (2011) A mechanochemical approach to porous silicon nanoparticles fabrication. Materials 4:1023–1033
Sailor MJ (2012) Porous silicon in practice: preparation, characterization, and applications. Wiley-VCH, Weinheim
Sailor MJ, Link JR (2005) Smart dust: nanostructured devices in a grain of sand. Chem Commun 11:1375–1383
Salonen J (2014) Drug delivery with porous silicon. In: Canham LT (ed) Handbook of porous silicon. Springer, Switzerland, p 909
Salonen J, Laitinen L, Kaukonen AM, Tuura J, Bjorkqvist M, Heikkila T, Vaha-Heikkila K, Hirvonen J, Lehto VP (2005) Mesoporous silicon microparticles for oral drug delivery: loading and release of five model drugs. J Control Release 108:362–374
Salonen J, Kaukonen AM, Hirvonen J, Lehto VP (2008) Mesoporous silicon in drug delivery applications. J Pharm Sci 97:632–653
Secret E, Smith K, Dubljevic V, Moore E, Macardle P, Delalat B, Rogers ML, Johns TG, Durand JO, Cunin F et al (2013) Antibody-functionalized porous silicon nanoparticles for vectorization of hydrophobic drugs. Adv Healthc Mater 2:718–727
Secret E, Maynadier M, Gallud A, Chaix A, Bouffard E, Gary-Bobo M, Marcotte N, Mongin O, El Cheikh K, Hugues V et al (2014) Two-photon excitation of porphyrin-functionalized porous silicon nanoparticles for photodynamic therapy. Adv Mater 26:7643–7648
Secret E, Leonard C, Kelly SJ, Uhl A, Cozzan C, Andrew JS (2016) Size control of porous silicon-based nanoparticles via pore-wall thinning. Langmuir 32:1166–1170
Serda RE, Go JH, Bhavane RC, Liu XW, Chiappini C, Decuzzi P, Ferrari M (2009) The association of silicon microparticles with endothelial cells in drug delivery to the vasculature. Biomaterials 30:2440–2448
Serda RE, Mack A, Pulikkathara M, Zaske AM, Chiappini C, Fakhoury JR, Webb D, Godin B, Conyers JL, Liu XW et al (2010) Cellular association and assembly of a multistage delivery system. Small 6:1329–1340
Singh N, Karambelkar A, Gu L, Lin K, Miller JS, Chen CS, Sailor MJ, Bhatia SN (2011) Bioresponsive mesoporous silica nanoparticles for triggered drug release. J Am Chem Soc 133:19582–19585
Sirbuly DJ, Lowman GM, Scott B, Stucky GD, Buratto SK (2003) Patterned microstructures of porous silicon by dry-removal soft lithography. Adv Mater 15:149
Swihart MT (2003) Vapor-phase synthesis of nanoparticles. Curr Opin Sol State Mater Sci 8:127–133
Tasciotti E, Liu XW, Bhavane R, Plant K, Leonard AD, Price BK, Cheng MMC, Decuzzi P, Tour JM, Robertson F et al (2008) Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications. Nat Nanotechnol 3:151–157
Teo EJ, Tavernier EP, Breese MBH, Bettiol AA, Watt F, Liu MH, Blackwood DJ (2004) Three-dimensional micromachining of silicon using a nuclear microprobe. Nucl Instrum Methods Phys Res Sect B 222:513–517
Tzur-Balter A, Shatsberg Z, Beckerman M, Segal E, Artzi N (2015) Mechanism of erosion of nanostructured porous silicon drug carriers in neoplastic tissues. Nat Commun 6:6208
Veinot JGC (2006) Synthesis, surface functionalization, and properties of freestanding silicon nanocrystals. Chem Commun 40:4160–4168
Win KY, Feng SS (2005) Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs. Biomaterials 26:2713–2722
Xiao L, Gu L, Howell SB, Sailor MJ (2011) Porous silicon nanoparticle photosensitizers for singlet oxygen and their phototoxicity against cancer cells. ACS Nano 5:3651–3659
Yong KT, Law WC, Hu R, Ye L, Liu LW, Swihart MT, Prasad PN (2013) Nanotoxicity assessment of quantum dots: from cellular to primate studies. Chem Soc Rev 42:1236–1250
Zhang XM, Neiner D, Wang SZ, Louie AY, Kauzlarich SM (2007) A new solution route to hydrogen-terminated silicon nanoparticles: synthesis, functionalization and water stability. Nanotechnology 18:095601
Zolnik BS, Gonzalez-Fernandez A, Sadrieh N, Dobrovolskaia MA (2010) Minireview: nanoparticles and the immune system. Endocrinology 151:458–465
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Sailor, M.J. (2018). Porous Silicon Nanoparticles. In: Canham, L. (eds) Handbook of Porous Silicon. Springer, Cham. https://doi.org/10.1007/978-3-319-71381-6_103
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DOI: https://doi.org/10.1007/978-3-319-71381-6_103
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