Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE)
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The primary goal of the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) trial has been to determine whether cognitive training interventions in the domains of memory, reasoning, and visual speed of processing can improve cognitively demanding everyday functioning activities (Jobe et al. 2001) (See “Cognitive Training”). The secondary goal was to determine the process by which the interventions impacted daily functioning, including whether improvement on the proximal cognitive outcomes of memory, reasoning, or speed mediated this process (Jobe et al. 2001; Gross et al. 2018). To date, ACTIVE is the largest and longest-running cognitive training trial for cognitively normal older adults, funded by NIH, and continues to be an important study for understanding how factors such as health, mood, self-efficacy, and cognitive impairment may moderate intervention effects.
Study Design and Features
ACTIVE is a multisite, randomized,...
- Ball K, Berch DB, Helmers KF, Jobe JB, Leveck MD, Marsiske M, Morris JN, Rebok GW, Smith DM, Tennstedt SL, Unverzagt FW, Willis SL, for the ACTIVE Study Group for the AS (2002) Effects of cognitive training interventions with older adults. JAMA 288:2271. https://doi.org/10.1001/jama.288.18.2271CrossRefGoogle Scholar
- Gross AL, Payne BR, Casanova R, Davoudzadeh P, Dzierzewski JM, Farias S, Giovannetti T, Ip EH, Marsiske M, Rebok GW, Schaie KW, Thomas K, Willis S, Jones RN (2018) The ACTIVE conceptual framework as a structural equation model. Exp Aging Res 44:1–17. https://doi.org/10.1080/0361073X.2017.1398802CrossRefGoogle Scholar
- Jobe JB, Smith DM, Ball K, Tennstedt SL, Marsiske M, Willis SL, Rebok GW, Morris JN, Helmers KF, Leveck MD, Kleinman K (2001) Active: a cognitive intervention trial to promote independence in older adults. Control Clin Trials 22:453–479. https://doi.org/10.1016/S0197-2456(01)00139-8CrossRefGoogle Scholar
- Marsiske M, Dzierzewski JM, Thomas KR, Kasten L, Jones RN, Johnson KE, Willis SL, Whitfield KE, Ball KK, Rebok GW (2013) Race-related disparities in 5-year cognitive level and change in untrained active participants. J Aging Health 25:103S–127S. https://doi.org/10.1177/0898264313497794CrossRefGoogle Scholar
- Rebok GW, Ball K, Guey LT, Jones RN, Kim H-Y, King JW, Marsiske M, Morris JN, Tennstedt SL, Unverzagt FW, Willis SL (2014) Ten-year effects of the advanced cognitive training for independent and vital elderly cognitive training trial on cognition and everyday functioning in older adults. J Am Geriatr Soc 62:16–24. https://doi.org/10.1111/jgs.12607CrossRefGoogle Scholar
- Unverzagt FW, Kasten L, Johnson KE, Rebok GW, Marsiske M, Koepke KM, Elias JW, Morris JN, Willis SL, Ball K, Rexroth DF, Smith DM, Wolinsky FD, Tennstedt SL (2007) Effect of memory impairment on training outcomes in ACTIVE. J Int Neuropsychol Soc 13:953–960. https://doi.org/10.1017/S1355617707071512CrossRefGoogle Scholar
- Wadley VG, Crowe M, Marsiske M, Cook SE, Unverzagt FW, Rosenberg AL, Rexroth D (2007) Changes in everyday function in individuals with psychometrically defined mild cognitive impairment in the advanced cognitive training for independent and vital elderly study. J Am Geriatr Soc 55:1192–1198. https://doi.org/10.1111/j.1532-5415.2007.01245.xCrossRefGoogle Scholar
- Willis SL, Tennstedt SL, Marsiske M, Ball K, Elias J, Koepke KM, Morris JN, Rebok GW, Unverzagt FW, Stoddard AM, Wright E, ACTIVE Study Group for the AS (2006) Long-term effects of cognitive training on everyday functional outcomes in older adults. JAMA 296:2805. https://doi.org/10.1001/jama.296.23.2805CrossRefGoogle Scholar
- Wolinsky FD, Unverzagt FW, Smith DM, Jones R, Wright E, Tennstedt SL (2006) The effects of the ACTIVE cognitive training trial on clinically relevant declines in health-related quality of life. J Gerontol Ser B Psychol Sci Soc Sci 61:S281–S287. https://doi.org/10.1093/geronb/61.5.S281CrossRefGoogle Scholar
- Wolinsky FD, Mahncke HW, Weg MWV, Martin R, Unverzagt FW, Ball KK, Jones RN, Tennstedt SL (2009b) The ACTIVE cognitive training interventions and the onset of and recovery from suspected clinical depression. J Gerontol Ser B Psychol Sci Soc Sci 64B:577–585. https://doi.org/10.1093/geronb/gbp061CrossRefGoogle Scholar
- Wolinsky FD, Vander Weg MW, Martin R, Unverzagt FW, Willis SL, Marsiske M, Rebok GW, Morris JN, Ball KK, Tennstedt SL (2010) Does cognitive training improve internal locus of control among older adults? J Gerontol Ser B Psychol Sci Soc Sci 65B:591–598. https://doi.org/10.1093/geronb/gbp117CrossRefGoogle Scholar