Encyclopedia of Gerontology and Population Aging

Living Edition
| Editors: Danan Gu, Matthew E. Dupre

Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE)

Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-69892-2_1075-1

Project Goals/Missions/Objectives

The primary goal of the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) trial has been to determine whether cognitive training interventions in the domains of memory, reasoning, and visual speed of processing can improve cognitively demanding everyday functioning activities (Jobe et al. 2001) (See “Cognitive Training”). The secondary goal was to determine the process by which the interventions impacted daily functioning, including whether improvement on the proximal cognitive outcomes of memory, reasoning, or speed mediated this process (Jobe et al. 2001; Gross et al. 2018). To date, ACTIVE is the largest and longest-running cognitive training trial for cognitively normal older adults, funded by NIH, and continues to be an important study for understanding how factors such as health, mood, self-efficacy, and cognitive impairment may moderate intervention effects.

Study Design and Features


ACTIVE is a multisite, randomized,...

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  1. Aiken Morgan AT, Marsiske M, Dzierzewski JM, Jones RN, Whitfield KE, Johnson KE, Cresci MK (2010) Race-related cognitive test bias in the active study: a mimic model approach. Exp Aging Res 36:426–452.  https://doi.org/10.1080/0361073X.2010.507427CrossRefGoogle Scholar
  2. Ball KK, Beard BL, Roenker DL, Miller RL, Griggs DS (1988) Age and visual search: expanding the useful field of view. J Opt Soc Am A 5:2210.  https://doi.org/10.1364/JOSAA.5.002210CrossRefGoogle Scholar
  3. Ball K, Berch DB, Helmers KF, Jobe JB, Leveck MD, Marsiske M, Morris JN, Rebok GW, Smith DM, Tennstedt SL, Unverzagt FW, Willis SL, for the ACTIVE Study Group for the AS (2002) Effects of cognitive training interventions with older adults. JAMA 288:2271.  https://doi.org/10.1001/jama.288.18.2271CrossRefGoogle Scholar
  4. Ball K, Edwards JD, Ross LA, McGwin G Jr (2010) Cognitive training decreases motor vehicle collision involvement of older drivers. J Am Geriatr Soc 58:2107–2113.  https://doi.org/10.1111/j.1532-5415.2010.03138.xCrossRefGoogle Scholar
  5. Ball KK, Ross LA, Roth DL, Edwards JD (2013) Speed of processing training in the ACTIVE study: how much is needed and who benefits? J Aging Health 25:65S–84S.  https://doi.org/10.1177/0898264312470167CrossRefGoogle Scholar
  6. Cook SE, Marsiske M, Thomas KR, Unverzagt FW, Wadley VG, Langbaum JBS, Crowe M (2013) Identification of mild cognitive impairment in ACTIVE: algorithmic classification and stability. J Int Neuropsychol Soc 19:73–87.  https://doi.org/10.1017/S1355617712000938CrossRefGoogle Scholar
  7. Edwards JD, Xu H, Clark DO, Guey LT, Ross LA, Unverzagt FW (2017) Speed of processing training results in lower risk of dementia. Alzheimer’s Dement 3:603–611.  https://doi.org/10.1016/j.trci.2017.09.002CrossRefGoogle Scholar
  8. Gross AL, Rebok GW (2011) Memory training and strategy use in older adults: results from the ACTIVE study. Psychol Aging 26:503–317.  https://doi.org/10.1037/a0022687CrossRefGoogle Scholar
  9. Gross AL, Brandt J, Bandeen-Roche K, Carlson MC, Stuart EA, Marsiske M, Rebok GW (2014) Do older adults use the method of loci? Results from the ACTIVE study. Exp Aging Res 40:140–163.  https://doi.org/10.1080/0361073X.2014.882204CrossRefGoogle Scholar
  10. Gross AL, Payne BR, Casanova R, Davoudzadeh P, Dzierzewski JM, Farias S, Giovannetti T, Ip EH, Marsiske M, Rebok GW, Schaie KW, Thomas K, Willis S, Jones RN (2018) The ACTIVE conceptual framework as a structural equation model. Exp Aging Res 44:1–17.  https://doi.org/10.1080/0361073X.2017.1398802CrossRefGoogle Scholar
  11. Jobe JB, Smith DM, Ball K, Tennstedt SL, Marsiske M, Willis SL, Rebok GW, Morris JN, Helmers KF, Leveck MD, Kleinman K (2001) Active: a cognitive intervention trial to promote independence in older adults. Control Clin Trials 22:453–479.  https://doi.org/10.1016/S0197-2456(01)00139-8CrossRefGoogle Scholar
  12. Marsiske M, Dzierzewski JM, Thomas KR, Kasten L, Jones RN, Johnson KE, Willis SL, Whitfield KE, Ball KK, Rebok GW (2013) Race-related disparities in 5-year cognitive level and change in untrained active participants. J Aging Health 25:103S–127S.  https://doi.org/10.1177/0898264313497794CrossRefGoogle Scholar
  13. Rebok GW, Balcerak LJ (1989) Memory self-efficacy and performance differences in young and old adults: the effect of mnemonic training. Dev Psychol 25:714–721.  https://doi.org/10.1037/0012-1649.25.5.714CrossRefGoogle Scholar
  14. Rebok GW, Langbaum JBS, Jones RN, Gross AL, Parisi JM, Spira AP, Kueider AM, Petras H, Brandt J (2013) Memory training in the ACTIVE study. J Aging Health 25:21S–42S.  https://doi.org/10.1177/0898264312461937CrossRefGoogle Scholar
  15. Rebok GW, Ball K, Guey LT, Jones RN, Kim H-Y, King JW, Marsiske M, Morris JN, Tennstedt SL, Unverzagt FW, Willis SL (2014) Ten-year effects of the advanced cognitive training for independent and vital elderly cognitive training trial on cognition and everyday functioning in older adults. J Am Geriatr Soc 62:16–24.  https://doi.org/10.1111/jgs.12607CrossRefGoogle Scholar
  16. Thomas KR, Marsiske M (2014) Verbal prompting to improve everyday cognition in MCI and unimpaired older adults. Neuropsychology 28:123–134.  https://doi.org/10.1037/neu0000039CrossRefGoogle Scholar
  17. Unverzagt FW, Kasten L, Johnson KE, Rebok GW, Marsiske M, Koepke KM, Elias JW, Morris JN, Willis SL, Ball K, Rexroth DF, Smith DM, Wolinsky FD, Tennstedt SL (2007) Effect of memory impairment on training outcomes in ACTIVE. J Int Neuropsychol Soc 13:953–960.  https://doi.org/10.1017/S1355617707071512CrossRefGoogle Scholar
  18. Unverzagt FW, Guey LT, Jones RN, Marsiske M, King JW, Wadley VG, Crowe M, Rebok GW, Tennstedt SL (2012) ACTIVE cognitive training and rates of incident dementia. J Int Neuropsychol Soc 18:669–677.  https://doi.org/10.1017/S1355617711001470CrossRefGoogle Scholar
  19. Wadley VG, Crowe M, Marsiske M, Cook SE, Unverzagt FW, Rosenberg AL, Rexroth D (2007) Changes in everyday function in individuals with psychometrically defined mild cognitive impairment in the advanced cognitive training for independent and vital elderly study. J Am Geriatr Soc 55:1192–1198.  https://doi.org/10.1111/j.1532-5415.2007.01245.xCrossRefGoogle Scholar
  20. Willis SL (1987) Cognitive training and everyday competence. Annu Rev Gerontol Geriatr 7:159–188.  https://doi.org/10.1891/0198-8794.7.1.159CrossRefGoogle Scholar
  21. Willis SL, Caskie GIL (2013) Reasoning training in the ACTIVE study. J Aging Health 25:43S–64S.  https://doi.org/10.1177/0898264313503987CrossRefGoogle Scholar
  22. Willis SL, Tennstedt SL, Marsiske M, Ball K, Elias J, Koepke KM, Morris JN, Rebok GW, Unverzagt FW, Stoddard AM, Wright E, ACTIVE Study Group for the AS (2006) Long-term effects of cognitive training on everyday functional outcomes in older adults. JAMA 296:2805.  https://doi.org/10.1001/jama.296.23.2805CrossRefGoogle Scholar
  23. Wolinsky FD, Unverzagt FW, Smith DM, Jones R, Wright E, Tennstedt SL (2006) The effects of the ACTIVE cognitive training trial on clinically relevant declines in health-related quality of life. J Gerontol Ser B Psychol Sci Soc Sci 61:S281–S287.  https://doi.org/10.1093/geronb/61.5.S281CrossRefGoogle Scholar
  24. Wolinsky FD, Mahncke HW, Kosinski M, Unverzagt FW, Smith DM, Jones RN, Stoddard A, Tennstedt SL (2009a) The ACTIVE cognitive training trial and predicted medical expenditures. BMC Health Serv Res 9:109.  https://doi.org/10.1186/1472-6963-9-109CrossRefGoogle Scholar
  25. Wolinsky FD, Mahncke HW, Weg MWV, Martin R, Unverzagt FW, Ball KK, Jones RN, Tennstedt SL (2009b) The ACTIVE cognitive training interventions and the onset of and recovery from suspected clinical depression. J Gerontol Ser B Psychol Sci Soc Sci 64B:577–585.  https://doi.org/10.1093/geronb/gbp061CrossRefGoogle Scholar
  26. Wolinsky FD, Vander Weg MW, Martin R, Unverzagt FW, Willis SL, Marsiske M, Rebok GW, Morris JN, Ball KK, Tennstedt SL (2010) Does cognitive training improve internal locus of control among older adults? J Gerontol Ser B Psychol Sci Soc Sci 65B:591–598.  https://doi.org/10.1093/geronb/gbp117CrossRefGoogle Scholar
  27. Zahodne LB, Meyer OL, Choi E, Thomas ML, Willis SL, Marsiske M, Gross AL, Rebok GW, Parisi JM (2015) External locus of control contributes to racial disparities in memory and reasoning training gains in ACTIVE. Psychol Aging 30:561–572.  https://doi.org/10.1037/pag0000042CrossRefGoogle Scholar

Authors and Affiliations

  1. 1.Department of PsychiatryUniversity of California, San Diego School of Medicine La JollaUSA
  2. 2.VA San Diego Healthcare System San DiegoUSA
  3. 3.Department of Mental HealthJohns Hopkins Bloomberg School of Public HealthBaltimoreUSA
  4. 4.Department of Psychiatry and Behavioral Sciences; Department of PsychologyUniversity of WashingtonSeattleUSA

Section editors and affiliations

  • Matthew E. Dupre
    • 1
    • 2
  1. 1.Department of Population Health Sciences, School of MedicineDuke UniversityDurhamUSA
  2. 2.Duke Clinical Research Institute, School of MedicineDuke UniversityDurhamUSA