Synonyms
B-cell lymphoma of BALT; Extranodal marginal zone lymphoma of bronchus-associated lymphoid tissue (BALT lymphoma, BALToma); Mucosa-associated lymphoid tissue lymphoma (MALT lymphoma); Pseudolymphoma; Pulmonary marginal zone lymphoma (P-MZL)
Definition
Bronchus-associated lymphoid tissue (BALT) is a submucosal lymphoid tissue specializing in mucosal defense. It consists of lymphoid aggregates associated with airways and is concentrated at the bifurcations of the bronchioles. Lymphoid aggregates occupy the lamina propria of the airway and are associated with a specialized overlying epithelial cell layer. It is composed of predominantly B cells (80%) with a much smaller proportion of CD4+ T cells (20%). Rare plasma cells and germinal centers can be seen. BALT most likely represents the site of local antibody production in response to introduction of the antigen through the epithelial cells of the airways. It is not present in the normal lung, but can be induced as a reaction to...
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References and Further Reading
Ahmed, S., Kussick, S. J., et al. (2004). Bronchial-associated lymphoid tissue lymphoma: a clinical study of a rare disease. European Journal of Cancer, 40(9), 1320–1326.
Arnaoutakis, K., & Oo, T. H. (2009). Bronchus-associated lymphoid tissue lymphomas. Southern Medical Journal, 102(12), 1229–1233.
Bae, Y. A., Lee, K. S., et al. (2008). Marginal zone b-cell lymphoma of bronchus-associated lymphoid tissue: imaging findings in 21 patents. Chest, 133(2), 433–440. Epub 2007 Dec 10.
Stefanovic, A., Morgensztern, D., et al. (2008). Pulmonary marginal zone lymphoma: a single case experience and review of the SEER database. Leukemia and Lymphoma, 49(7), 1311–1320.
Tomashefski, J. F., Jr., Cagle, F. T., Farver, C. F., & Fraire, A. E. (2008). Dail and Hammar’s pulmonary pathology (3rd ed.). New York: Springer.
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Golardi, N., Borczuk, A., Cagle, P.T. (2018). Bronchus-Associated Lymphoid Tissue Lymphoma. In: Cagle, P.T., Kerr, K.M. (eds) Pulmonary Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-69263-0_2741
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DOI: https://doi.org/10.1007/978-3-319-69263-0_2741
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