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DRAK2

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References

  • Al-Qahtani A, Xu Z, Zan H, Walsh CM, Casali P. A role for DRAK2 in the germinal center reaction and the antibody response. Autoimmunity. 2008;41:341–52.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Bialik S, Kimchi A. The death-associated protein kinases: structure, function, and beyond. Annu Rev Biochem. 2006;75:189–210.

    Article  CAS  PubMed  Google Scholar 

  • Doherty GA, Byrne SM, Austin SC, Scully GM, Sadlier DM, Neilan TG, Kay EW, Murray FE, Fitzgerald DJ. Regulation of the apoptosis-inducing kinase DRAK2 by cyclooxygenase-2 in colorectal cancer. Br J Cancer. 2009;101:483–91.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Friedrich ML, Wen BG, Bain G, Kee BL, Katayama C, Murre C, Hedrick SM, Walsh CM. DRAK2, a lymphoid-enriched DAP kinase, regulates the TCR activation threshold during thymocyte selection. Int Immunol. 2005;17:1379–90.

    Article  CAS  PubMed  Google Scholar 

  • Friedrich ML, Cui M, Hernandez JB, Weist BM, Andersen HM, Zhang X, Huang L, Walsh CM. Modulation of DRAK2 autophosphorylation by antigen receptor signaling in primary lymphocytes. J Biol Chem. 2007;282:4573–84.

    Article  CAS  PubMed  Google Scholar 

  • Gatzka M, Newton RH, Walsh CM. Negative regulation of TCR signaling in immunological tolerance: taming good and evil. Curr Immunol Rev J Immunol. 2009a;183(1):285–97.

    CAS  Google Scholar 

  • Gatzka M, Newton RH, Walsh CM. Altered thymic selection and increased autoimmunity caused by ectopic expression of DRAK2 during T cell development. J Immunol. 2009b;183:285–97.

    Article  PubMed  CAS  Google Scholar 

  • Kuwahara H, Nakamura N, Kanazawa H. Nuclear localization of the serine/threonine kinase DRAK2 is involved in UV-induced apoptosis. Biol Pharm Bull. 2006;29:225–33.

    Article  CAS  PubMed  Google Scholar 

  • Kuwahara H, Nishizaki M, Kanazawa H. Nuclear localization signal and phosphorylation of Serine350 specify intracellular localization of DRAK2. J Biochem. 2008;143:349–58.

    Article  CAS  PubMed  Google Scholar 

  • Mao J, Qiao X, Luo H, Wu J. Transgenic drak2 overexpression in mice leads to increased T cell apoptosis and compromised memory T cell development. J Biol Chem. 2006;281:12587–95.

    Article  CAS  PubMed  Google Scholar 

  • Mao J, Luo H, Han B, Bertrand R, Wu J. Drak2 is upstream of p70S6 kinase: its implication in cytokine-induced islet apoptosis, diabetes, and islet transplantation. J Immunol. 2009;182:4762–70.

    Article  CAS  PubMed  Google Scholar 

  • Matsumoto M, Miyake Y, Nagita M, Inoue H, Shitakubo D, Takemoto K, Ohtsuka C, Murakami H, Nakamura N, Kanazawa H. A serine/threonine kinase which causes apoptosis-like cell death interacts with a calcineurin B-like protein capable of binding Na(+)/H(+) exchanger. J Biochem. 2001;130:217–25.

    Article  CAS  PubMed  Google Scholar 

  • McGargill MA, Wen BG, Walsh CM, Hedrick SM. A deficiency in Drak2 results in a T cell hypersensitivity and an unexpected resistance to autoimmunity. Immunity. 2004;21:781–91.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • McGargill MA, Choy C, Wen BG, Hedrick SM. Drak2 regulates the survival of activated T cells and is required for organ-specific autoimmune disease. J Immunol. 2008;181:7593–605.

    Article  PubMed  CAS  Google Scholar 

  • Newton RH, Leverrier S, Srikanth S, Gwack Y, Cahalan MD, Walsh CM. Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation. J Immunol. 2011;186(2):940–50.

    Article  CAS  PubMed  Google Scholar 

  • Pentcheva-Hoang T, Corse E, Allison JP. Negative regulators of T-cell activation: potential targets for therapeutic intervention in cancer, autoimmune disease, and persistent infections. Immunol Rev. 2009;229:67–87.

    Article  CAS  PubMed  Google Scholar 

  • Ramos SJ, Hardison JL, Stiles LN, Lane TE, Walsh CM. Anti-viral effector T cell responses and trafficking are not dependent upon DRAK2 signaling following viral infection of the central nervous system. Autoimmunity. 2007;40:54–65.

    Article  CAS  PubMed  Google Scholar 

  • Ramos SJ, Hernandez JB, Gatzka M, Walsh CM. Enhanced T cell apoptosis within Drak2-deficient mice promotes resistance to autoimmunity. J Immunol. 2008;181:7606–16.

    Article  PubMed  CAS  Google Scholar 

  • Sanjo H, Kawai T, Akira S. DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis. J Biol Chem. 1998;273:29066–71.

    Article  CAS  PubMed  Google Scholar 

  • Schaumburg CS, Gatzka M, Walsh CM, Lane TE. DRAK2 regulates memory T cell responses following murine coronavirus infection. Autoimmunity. 2007;40:483–8.

    Article  CAS  PubMed  Google Scholar 

  • Wu C, Orozco C, Boyer J, Leglise M, Goodale J, Batalov S, Hodge CL, Haase J, Janes J, Huss 3rd JW, Su AI. BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources. Genome Biol. 2009;10:R130.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Acknowledgments

This work was supported by the National Institutes of Health (AI63419); the Arthritis National Research Foundation; the National Multiple Sclerosis Society; and the Juvenile Diabetes Research Foundation. R.H.N. was supported by National Institutes of Health Immunology Research Training Grant T32 AI-060573.

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Correspondence to Craig M. Walsh .

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Hernandez, J.B., Newton, R.H., Weist, B.M., Walsh, C.M. (2018). DRAK2. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_85

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