Historical Background
The MRC2 gene encodes the constitutively recycling type I transmembrane receptor Endo180 (Wu et al. 1996; Sheikh et al. 2000; Isacke et al. 1990), which is also cited in the literature as urokinase plasminogen activator receptor associated protein (uPARAP) following its identification as part of a trimolecular complex with pro-urokinase plasminogen activator (pro-uPA) and its receptor urokinase plasminogen activator receptor (uPAR) (Behrendt et al. 2000). Endo180 is a member of the mannose receptor family, which also includes the mannose receptor (MR; CD206), M-type phospholipase A2 receptor, and DEC-205 (CD205) (East and Isacke 2002). The constitutive recycling of Endo180 between clathrin-coated pits at the plasma membrane...
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Behrendt N, Jensen ON, Engelholm LH, Mortz E, Mann M, Dano K. A urokinase receptor-associated protein with specific collagen binding properties. J Biol Chem. 2000;275:1993–2002.
Boskovic J, Arnold JN, Stilion R, Gordon S, Sim RB, Rivera-Calzada A, et al. Structural model for the mannose receptor family uncovered by electron microscopy of Endo180 and the mannose receptor. J Biol Chem. 2006;281:8780–7.
East L, Isacke CM. The mannose receptor family. Biochim Biophys Acta. 2002;1572:364–86.
East L, Rushton S, Taylor ME, Isacke CM. Characterization of sugar binding by the mannose receptor family member, Endo180. J Biol Chem. 2002;277:50469–75.
East L, McCarthy A, Wienke D, Sturge J, Ashworth A, Isacke CM. A targeted deletion in the endocytic receptor gene Endo180 results in a defect in collagen uptake. EMBO Rep. 2003;4:710–6.
Engelholm LH, List K, Netzel-Arnett S, Cukierman E, Mitola DJ, Aaronson H, et al. uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion. J Cell Biol. 2003;160:1009–15.
Howard MJ, Isacke CM. The C-type lectin receptor Endo180 displays internalization and recycling properties distinct from other members of the mannose receptor family. J Biol Chem. 2002;277:32320–31.
Huijbers IJ, Iravani M, Popov S, Robertson D, Al-Sarraj S, Jones C, et al. A role for fibrillar collagen deposition and the collagen internalization receptor Endo180 in glioma invasion. PLoS One. 2010;5:e9808.
Isacke CM, van der Geer P, Hunter T, Trowbridge IS. p180, a novel recycling transmembrane glycoprotein with restricted cell type expression. Mol Cell Biol. 1990;10:2606–18.
Jansen KM, Pavlath GK. Mannose receptor regulates myoblast motility and muscle growth. J Cell Biol. 2006;174:403–13.
Kogianni G, Walker MM, Waxman J, Sturge J. Endo180 expression with cofunctional partners MT1-MMP and uPAR-uPA is correlated with prostate cancer progression. Eur J Cancer. 2009;45:685–93.
Rivera-Calzada A, Robertson D, MacFadyen JR, Boskovic J, Isacke CM, Llorca O. Three-dimensional interplay among the ligand-binding domains of the urokinase-plasminogen-activator-receptor-associated protein, Endo180. EMBO Rep. 2003;4:807–12.
Sheikh H, Yarwood H, Ashworth A, Isacke CM. Endo180, an endocytic recycling glycoprotein related to the macrophage mannose receptor is expressed on fibroblasts, endothelial cells and macrophages and functions as a lectin receptor. J Cell Sci. 2000;113:1021–32.
Sturge J, Wienke D, East L, Jones GE, Isacke CM. GPI-anchored uPAR requires Endo180 for rapid directional sensing during chemotaxis. J Cell Biol. 2003;162:789–94.
Sturge J, Wienke D, Isacke CM. Endosomes generate localized Rho-ROCK-MLC2-based contractile signals via Endo180 to promote adhesion disassembly. J Cell Biol. 2006;175:337–47.
Takahashi S, Yamada-Okabe H, Hamada K, Ohta S, Kawase T, Yoshida K, et al. Downregulation of uPARAP mediates cytoskeletal rearrangements and decreases invasion and migration properties in glioma cells. J Neurooncol. 2010. https://doi.org/10.1007/s11060-010-0398-z.
Thomas EK, Nakamura M, Wienke D, Isacke CM, Pozzi A, Liang P. Endo180 binds to the C-terminal region of type I collagen. J Biol Chem. 2005;280:22596–605.
Wienke D, MacFadyen JR, Isacke CM. Identification and characterization of the endocytic transmembrane glycoprotein Endo180 as a novel collagen receptor. Mol Biol Cell. 2003;14:3592–604.
Wienke D, Davies GC, Johnson DA, Sturge J, Lambros MB, Savage K, et al. The collagen receptor Endo180 (CD280) is expressed on basal-like breast tumor cells and promotes tumor growth in vivo. Cancer Res. 2007;67:10230–40.
Wu K, Yuan J, Lasky LA. Characterization of a novel member of the macrophage mannose receptor type C lectin family. J Biol Chem. 1996;271:21323–30.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG
About this entry
Cite this entry
Gronau, J.H., Isacke, C.M., Sturge, J. (2018). MRC2. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_79
Download citation
DOI: https://doi.org/10.1007/978-3-319-67199-4_79
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-67198-7
Online ISBN: 978-3-319-67199-4
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences