Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

MRC2

  • Julian Hendrik Gronau
  • Clare M. Isacke
  • Justin Sturge
Reference work entry
First Online:
DOI: https://doi.org/10.1007/978-3-319-67199-4_79
How to cite

Synonyms

 CD280;  Collagen-binding factor Endo180;  C-type mannose receptor 2;  Endo180;  Endocytic receptor 180;  Macrophage mannose receptor 2;  Mannose receptor, C-type 2;  Urokinase-type plasminogen activator receptor-associated protein (uPARAP)

Historical Background

The MRC2 gene encodes the constitutively recycling type I transmembrane receptor Endo180 (Wu et al. 1996; Sheikh et al. 2000; Isacke et al. 1990), which is also cited in the literature as urokinase plasminogen activator receptor associated protein (uPARAP) following its identification as part of a trimolecular complex with pro-urokinase plasminogen activator (pro-uPA) and its receptor urokinase plasminogen activator receptor ( uPAR) (Behrendt et al. 2000). Endo180 is a member of the mannose receptor family, which also includes the mannose receptor (MR; CD206), M-type phospholipase A2 receptor, and DEC-205 (CD205) (East and Isacke 2002). The constitutive recycling of Endo180 between clathrin-coated pits at the plasma...

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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Julian Hendrik Gronau
    • 1
  • Clare M. Isacke
    • 2
  • Justin Sturge
    • 1
  1. 1.Division of Cancer, Department of Surgery and CancerImperial College London, Hammersmith HospitalLondonUK
  2. 2.Breakthrough Breast Cancer Research CentreThe Institute of Cancer ResearchLondonUK