Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

G Protein Beta/Gamma

  • Denis J. DupréEmail author
  • Terence E. Hébert
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_75



Five different isoforms of Gbeta have been identified, numbered 1 to 5. Ggamma isoforms are numbered from 1 to 5 and 7 to 13.

G protein beta5 can also be known as Flailer, Flail, Flr, Hug.

G protein gamma2 is also known as G protein gamma6.

Historical Background

G protein β and γ subunits were first discovered as components of G proteins over 30 years ago. Since then, their role has evolved significantly from simple inhibitors of  G protein αsubunits to independent signaling regulators modulating a number of different cellular effectors. Although several isoforms of Gα were cloned in the early 1980s, it was not until 1986 that the transducin Gβ subunit was cloned...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Pharmacology, Faculty of MedicineDalhousie UniversityHalifaxCanada
  2. 2.Department of Pharmacology and TherapeuticsMcGill UniversityMontréalCanada