Synonyms
Historical Background
Flotillin-1 was originally identified in 1997, when Bickel et al. analyzed caveolin-rich membrane fractions from mouse lung and isolated a 45 kDa protein that was microsequenced. Degenerate primers were designed from the peptide sequences and used for PCR of mouse lung cDNA. The PCR-product was then used as a probe for screening of a 3T3-L1 adipocyte cDNA library. The characterized sequence showed similarity to the ESA protein. An antipeptide antibody identified a 47 kDa protein on Western blots. Because this protein was detected in floating, caveolin-rich, Triton X-100-insoluble membrane fractions, it was termed “flotillin-1.” The similar ESA protein (47% identity) was renamed as “flotillin-2.” Also in 1997, Schulte et al. identified and characterized two proteins that were induced in regenerating fish retinal ganglion cell axons after injury and thus were named “reggie-1” and “reggie-2.” In 1998, Lang et al. cloned the rat reggie...
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Kurrle N, Völlner F, Eming R, Hertl M, Banning A, Tikkanen R. Flotillins directly interact with gamma-catenin and regulate epithelial cell-cell adhesion. PLoS One. 2013;8:e84393.
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Liu J, Deyoung SM, Zhang M, Dold LH, Saltiel AR. The stomatin/prohibitin/flotillin/HflK/C domain of flotillin-1 contains distinct sequences that direct plasma membrane localization and protein interactions in 3T3-L1 adipocytes. J Biol Chem. 2005;280:16125–34.
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Rajendran L, Masilamani M, Solomon S, Tikkanen R, Stuermer CA, Plattner H, Illges H. Asymmetric localization of flotillins/reggies in preassembled platforms confers inherent polarity to hematopoietic cells. Proc Natl Acad Sci USA. 2003;100:8241–6.
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Solis GP, Hülsbusch N, Radon Y, Katanaev VL, Plattner H, Stuermer CA. Reggies/flotillins interact with Rab11a and SNX4 at the tubulovesicular recycling compartment and function in transferrin receptor and E-cadherin trafficking. Mol BiolCell. 2013;24:2689–702.
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Sugawara Y, Nishii H, Takahashi T, Yamauchi J, Mizuno N, Tago K, Itoh H. The lipid raft proteins flotillins/reggies interact with Galphaq and are involved in Gq-mediated p38 mitogen-activated protein kinase activation through tyrosine kinase. Cell Signal. 2007;19:1301–8.
Swanwick CC, Shapiro ME, Yi Z, Chang K, Wenthold RJ. NMDA receptors interact with flotillin-1 and −2, lipid raft-associated proteins. FEBS Lett. 2009;583:1226–30.
Tomasovic A, Traub S, Tikkanen R. Molecular networks in FGF signaling: flotillin-1 and cbl-associated protein compete for the binding to fibroblast growth factor receptor substrate 2. PLoS One. 2012;7:e29739.
Vollner F, Ali J, Kurrle N, Exner Y, Eming R, Hertl M, Banning A, Tikkanen R. Loss of flotillin expression results in weakened desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes. Sci Rep. 2016;6:28820.
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Prohaska, R., Salzer, U. (2018). Flotillin-1 (FLOT1). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_645
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DOI: https://doi.org/10.1007/978-3-319-67199-4_645
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