Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Keiko Matsuda
  • Michisuke YuzakiEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_643


Historical Background

In 1984, the cerebellum-specific hexadecapeptide “cerebellin” was identified and shown to be concentrated in the synaptosomal compartment (Slemmon et al. 1984). Although “precerebellin” was originally identified as a precursor of cerebellin, the cerebellin peptide is not flanked by the classical dibasic amino acids observed in many neuropeptide precursors (Urade et al. 1991). In addition, precerebellin clearly belongs to the C1q family, whose members, such as C1q, adiponectin (Adipoq), and collagen X, are secreted and are involved in various intercellular functions (Yuzaki 2008). Indeed, full-length, uncleaved precerebellin is secreted from cerebellar granule cells (Bao et al. 2005; Iijima et al. 2007). Therefore, it is now evident that precerebellin is the actual signaling molecule itself, which should be referred to as Cbln1, although the cerebellin peptide may have additional functions.

Basic Features

Cbln1 is predominantly expressed in...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of PhysiologyKeio University School of MedicineTokyoJapan
  2. 2.Department of NeurophysiologySchool of Medicine, Keio UniversityShinjuku-ku, TokyoJapan