Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Striatal-Enriched Protein-Tyrosine Phosphatase (STEP)

  • Pradeep Kurup
  • Jian Xu
  • Manavi Chatterjee
  • Susan Goebel-Goody
  • Surojit Paul
  • Paul LombrosoEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_630


Historical Background

Protein-tyrosine phosphatases (PTPs) play a significant role in diverse signaling mechanisms ranging from cellular differentiation to synaptic plasticity (Paul and Lombroso 2003; Tonks 2006). STriatal-Enriched protein-tyrosine Phosphatase (STEP) is a brain-specific protein tyrosine phosphatase belonging to the non-receptor tyrosine phosphatase family. Although enriched in the striatum, it is also localized to neurons in the cortex, hippocampus, and related brain regions (Boulanger et al. 1995). Interestingly, it is absent in the cerebellum, where a highly related PTP, PTP-STEP-like, is present (Watanabe et al. 1998). STEP exists as two major isoforms, named after their mobility in SDS-PAGE and designated STEP61and...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Pradeep Kurup
    • 1
  • Jian Xu
    • 1
  • Manavi Chatterjee
    • 1
  • Susan Goebel-Goody
    • 1
  • Surojit Paul
    • 1
    • 2
  • Paul Lombroso
    • 1
    Email author
  1. 1.Child Study CenterYale University, School of MedicineNew HavenUSA
  2. 2.NeurologyUniversity of New Mexico Health Sciences CenterAlbuquerqueUSA