PRAP (Pyk2/RAFTK-associated protein); RA70 (Retinoic acid-induced protein 70); SAPS (Src-associated adaptor protein with PH and SH3 domains); SKAP2/SCAP2 (Src kinase-associated phosphoprotein 2); SKAP55 homologue (Src kinase-associated phosphoprotein of 55 kDa homologue); SKAP55-R (Src kinase-associated phosphoprotein 55-related protein)
SKAP-HOM was originally described in 1998 as a protein homologous to the cytosolic adaptor protein SKAP55 (Marie-Cardine et al. 1998). Using the recombinant SH2 domain of the Src protein tyrosine kinase Fyn expressed as a GST fusion protein, SKAP55 and SKAP-HOM were purified from lysates of pervanadate-treated human T cells. Furthermore, it was demonstrated that SKAP-HOM acts as a substrate for the Src kinase Fyn and that it binds the adaptor molecule FYB/SLAP/ ADAP. At the same time, Liu et al. reported the identification and the molecular cloning of a protein termed SKAP55-R. Using the yeast two-hybrid system...
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