Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Annegret Reinhold
  • Burkhart L. SchravenEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_629


Historical Background

SKAP-HOM was originally described in 1998 as a protein homologous to the cytosolic adaptor protein SKAP55 (Marie-Cardine et al. 1998). Using the recombinant SH2 domain of the  Src protein tyrosine kinase Fyn expressed as a GST fusion protein, SKAP55 and SKAP-HOM were purified from lysates of pervanadate-treated human T cells. Furthermore, it was demonstrated that SKAP-HOM acts as a substrate for the Src kinase Fyn and that it binds the adaptor molecule FYB/SLAP/ ADAP. At the same time, Liu et al. reported the identification and the molecular cloning of a protein termed SKAP55-R. Using the yeast two-hybrid system...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Institute for Molecular and Clinical ImmunologyOtto von Guericke University MagdeburgMagdeburgGermany