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Encyclopedia of Signaling Molecules pp 5873–5883Cite as

VAMP1/2/3/7

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Overview

Intracellular membrane trafficking in eukaryotes is a multiple step process consisting in the budding of vesicles from a donor compartment, their translocation into the cytoplasm along cytoskeletal elements, their tethering, and subsequent fusion with the membrane of the target compartment. Membrane fusion is based on SNARE proteins, classified into two categories, vesicular (v)-SNAREs and target (t)-SNAREs present on the acceptor membrane. It is the specific pairing of v-SNAREs with their cognate t-SNAREs in trans which is responsible for bringing the lipid bilayers close together, and the zippering of SNAREs provides the required energy for membrane fusion (Fig. 1). This review focuses on the discovery of SNAREs and then on four of the nine v-SNAREs: the clostridial neurotoxin sensitive VAMPs 1, 2, and 3 and on Tetanus neurotoxin-Insensitive Vesicle-Associated Membrane Protein, TI-VAMP/VAMP7. VAMP7, unlike the first ones, possess a long amino-terminal domain called the...

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Acknowledgments

We apologize to all the authors that are not cited in the text due to strong reference limitation. Our work is supported in part by the Institut National de la Santé et de la Recherche Médicale (INSERM), and the Centre National de la Recherche Scientifique (CNRS) and grants from the Fondation pour la Recherche Médicale (FRM), the Association pour la Recherche sur le Cancer (ARC), and the Who am I? Labex (Idex ANR-11-IDEX-0005-01).

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Authors and Affiliations

  1. Institut Jacques Monod, UMR 7592, CNRS, Paris, France

    Thierry GALLI & Véronique Proux-Gillardeaux

  2. Membrane Traffic in Health and Disease, INSERM ERL U950, Université Paris Diderot, Paris 7, 75013, Paris, France

    Thierry GALLI & Véronique Proux-Gillardeaux

  3. Institut Jacques Monod, Bat. Buffon, 15 rue Hélène Brion, 75013, Paris, France

    Véronique Proux-Gillardeaux

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  1. Thierry GALLI
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Correspondence to Thierry GALLI or Véronique Proux-Gillardeaux .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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GALLI, T., Proux-Gillardeaux, V. (2018). VAMP1/2/3/7. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_627

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