Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Dimitra Virla
  • Christos Tsatsanis
  • Aristides G. EliopoulosEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_626


Historical Background

The Tpl2 gene, also known as COT and MAP3K8 (Vougioukalaki et al. 2011), was independently discovered by three research teams in the early 1990s. COT (Cancer Osaka thyroid) was initially described by Miyoshi et al. as a putative human proto-oncogene, isolated from a human thyroid carcinoma cell line and discovered to have a rearranged 3′ end in the last coding exon (Miyoshi et al. 1991). The rat homologue of COT, named tumor progression locus ( Tpl2), was identified by Tsichlis et al. as a proto-oncogene that is activated by provirus integration in Moloney murine leukemia virus (MoMuLV)-induced T-cell lymphomas and capable to transform NIH 3T3 fibroblasts in vitro (Patriotis et al. 1993). In mice, the Tpl2gene locus is also targeted by provirus insertion in mouse mammary tumor virus (MMTV)-associated mammary carcinomas in mice...
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Dimitra Vyrla was supported through the action “Funding of Postdoctoral Researchers” of the Operational Program “Development of Human Resources, Education and Lifelong Learning,” 2014–2020, implemented by State Schlolarships Foundation (IKY) and cofinanced by the European Social Fund and the Greek State.


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Dimitra Virla
    • 1
  • Christos Tsatsanis
    • 3
  • Aristides G. Eliopoulos
    • 1
    • 2
    Email author
  1. 1.Molecular and Cellular Biology Laboratory, Division of Basic SciencesUniversity of Crete Medical SchoolHeraklionGreece
  2. 2.Institute for Molecular Biology and Biotechnology, Foundation of Research and Technology Hellas (FORTH)HeraklionGreece
  3. 3.Department of Clinical ChemistryUniversity of Crete Medical SchoolHeraklionGreece