Synonyms
Historical Background
The homeodomain-interacting protein kinase 2 (HIPK2) was first described in 1998 as member of a novel protein kinase family (HIPK1-3) able to interact with homeodomain transcription factors of the NK-2 family and to enhance their repressor activity (Kim et al. 1998). Over the next years, it was shown that HIPK2 very likely is an autophosphorylating Ser/Thr kinase which localizes to nuclear speckles (see Fig. 1), and a number of interaction partners and putative targets such as the death receptor CD95, the corepressor Groucho, or a STAT3 peptide were identified. The HIPK2 genes were mapped to Chr. 7q32–42 in humans and to Chr. 6B in the mouse.
The HIPK2 protein. (a) Schematic drawing of important domains and interactions of the HIPK2 protein. NLS, nuclear localization signal; SIM, SUMO interaction motif. (b) Nuclear speckle localization of exogenously expressed GFP-HIPK2 in U2OS cells
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References
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Hofmann, T.G., Krieghoff-Henning, E. (2018). HIPK2. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_618
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DOI: https://doi.org/10.1007/978-3-319-67199-4_618
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