Skip to main content
SpringerLink
Log in

Endothelin A Receptor (ETAR)

  • Reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 123 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 4,499.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 4,499.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Abman SH. Role of endothelin receptor antagonists in the treatment of pulmonary arterial hypertension. Annu Rev Med. 2009;60:13–23.

    Article  CAS  PubMed  Google Scholar 

  • Bagnato A, Loizidou M, Pflug BR, Curwen J, Growcott J. Role of the endothelin axis and its antagonists in the treatment of cancer. Br J Pharmacol. 2011;163:220–33.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Barnes PJ. Pulmonary pharmacology. In: Brunton L, Chabner B, Knollmann B, editors. The pharmacological basis of therapeutics. 12th ed. New York: McGraw-Hill; 2011. p. 1031–66.

    Google Scholar 

  • Barton M, Yanagisawa M. Endothelin: 20 years from discovery to therapy. Can J Physiol Pharmacol. 2008;86:485–98.

    Article  CAS  PubMed  Google Scholar 

  • Bkaily G, Avedanian L, Al-Khoury J, Provost C, Nader M, D'Orléans-Juste P, Jacques D. Nuclear membrane receptors for ET-1 in cardiovascular function. Am J Phys. 2011;300:R251–63.

    CAS  Google Scholar 

  • Davenport AP. International Union of Pharmacology. XXIX. Update on endothelin receptor nomenclature. Pharmacol Rev. 2002;54:219–26.

    Article  CAS  PubMed  Google Scholar 

  • Dhaun N, Macintyre IM, Kerr D, Melville V, Johnston NR, Haughie S, et al. Selective endothelin-a receptor antagonism reduces proteinuria, blood pressure, and arterial stiffness in chronic proteinuric kidney disease. Hypertension. 2011;57:772–9.

    Article  CAS  PubMed  Google Scholar 

  • Edvinsson L, Povlsen GK. Late cerebral ischaemia after subarachnoid haemorrhage: is cerebrovascular receptor upregulation the mechanism behind? Acta Physiol (Oxford). 2011;203:209–24.

    Article  CAS  Google Scholar 

  • Evans NJ, Walker JW. Endothelin receptor dimers evaluated by FRET, ligand binding, and calcium mobilization. Biophys J. 2008;95:483–92.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hilal-Dandan R, Brunton LL. Endothelin type A receptor. 2010. http://www.signaling-gateway.org/molecule/query?afcsid=A.000836. Accessed 30 Mar 2011.

  • Hilal-Dandan R, Ramirez MT, Villegas S, Gonzalez A, Endo-Mochizuki Y, Brown JH, et al. Endothelin ETA receptor regulates signaling and ANF gene expression via multiple G protein-linked pathways. Am J Phys. 1997;272:H130–7.

    CAS  Google Scholar 

  • Ivey ME, Osman N, Little PJ. Endothelin-1 signalling in vascular smooth muscle: pathways controlling cellular functions associated with atherosclerosis. Atherosclerosis. 2008;199:237–47.

    Article  CAS  PubMed  Google Scholar 

  • Khimji AK, Rockey DC. Endothelin – biology and disease. Cell Signal. 2010;22:1615–25.

    Article  CAS  PubMed  Google Scholar 

  • Khodorova A, Montmayeur JP, Strichartz G. Endothelin receptors and pain. J Pain. 2009;10:4–28.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kohan DE. Endothelin, hypertension and chronic kidney disease: new insights. Curr Opin Nephrol Hypertens. 2010;19:134–9.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kuc RE, Maguire JJ, Davenport AP. Quantification of endothelin receptor subtypes in peripheral tissues reveals downregulation of ET(A) receptors in ET(B)-deficient mice. Exp Biol Med (Maywood). 2006;231:741–5.

    CAS  Google Scholar 

  • Motte S, McEntee K, Naeije R. Endothelin receptor antagonists. Pharmacol Ther. 2006;110:386–414.

    Article  CAS  PubMed  Google Scholar 

  • Paasche JD, Attramadal T, Kristiansen K, Oksvold MP, Johansen HK, Huitfeldt HS, et al. Subtype-specific sorting of the ETA endothelin receptor by a novel endocytic recycling signal for G protein-coupled receptors. Mol Pharmacol. 2005;67:1581–90.

    Article  CAS  PubMed  Google Scholar 

  • Rosano L, Cianfrocca R, Masi S, Spinella F, Di Castro V, Biroccio A, et al. Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis. Proc Natl Acad Sci U S A. 2009;106:2806–11.

    Article  PubMed  PubMed Central  Google Scholar 

  • Sato T, Kurihara Y, Asai R, Kawamura Y, Tonami K, Uchijima Y, et al. An endothelin-1 switch specifies maxillomandibular identity. Proc Natl Acad Sci U S A. 2008;105:18806–11.

    Article  PubMed  PubMed Central  Google Scholar 

  • Schneider MP, Boesen EI, Pollock DM. Contrasting actions of endothelin ET(A) and ET(B) receptors in cardiovascular disease. Annu Rev Pharmacol Toxicol. 2007;47:731–59.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Takigawa M, Sakurai T, Kasuya Y, Abe Y, Masaki T, Goto K. Molecular identification of guanine-nucleotide-binding regulatory proteins which couple to endothelin receptors. Eur J Biochem. 1995;228:102–8.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Pharmacology, University of California San Diego, La Jolla, San Diego, CA, 92093-0636, USA

    Randa Hilal-Dandan & Laurence L. Brunton

Authors
  1. Randa Hilal-Dandan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Laurence L. Brunton
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Randa Hilal-Dandan .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Hilal-Dandan, R., Brunton, L.L. (2018). Endothelin A Receptor (ETAR). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_616

Download citation

Publish with us

Policies and ethics

Search

Navigation