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Encyclopedia of Signaling Molecules pp 877–886Cite as

CD3ζ

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Synonyms

ζ; CD247; TCRζ

Introduction

CD3ζ is a homodimer-forming type 1 transmembrane (TM) protein and is part of the T cell antigen receptor (TCR) complex along with TCRαβ, CD3γε, and CD3δε dimers expressed on the surface of T cells (Figs. 1 and 2). T cells are an important component of the vertebrate adaptive immune system that are activated via TCR by the peptides generated from infectious agents and presented on major histocompatibility complex (MHC) molecules on the surface of cells. CD3ζ possesses a small extracellular part, a TM region, and a long cytoplasmic part that contains three immunoreceptor tyrosine-based activation motifs (ITAMs), which correspond to the six tyrosines that get phosphorylated upon antigen binding to the extracellular part of TCRαβ. Phosphorylation subsequently activates several downstream signaling cascades. Hence, CD3ζ plays a vital role in the activation of a T cell. CD3ζ is also part of the pre-TCR in pre-T cells and the γδTCR in γδ T cells that...

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Authors and Affiliations

  1. Department of Immunology, Institute for Biology III, University of Freiburg, Schänzlestr. 18, 79104, Freiburg, Germany

    Anna Morath, Sumit Deswal & Wolfgang W. A. Schamel

  2. Centre for Biological Signaling Studies (BIOSS), University of Freiburg, Schänzlestr. 18, 79104, Freiburg, Germany

    Anna Morath & Wolfgang W. A. Schamel

  3. Centre of Chronic Immunodeficiency (CCI), University Medical Center Freiburg and University of Freiburg, Freiburg, Germany

    Anna Morath & Wolfgang W. A. Schamel

  4. Spemann Graduate School of Biology and Medicine, University of Freiburg, Freiburg, Germany

    Anna Morath

  5. Max Planck Institute of Immunobiology, Stübeweg 51, 79108, Freiburg, Germany

    Sumit Deswal

  6. Research Institute of Molecular Pathology, Dr. Bohr Gasse 7, 1030, Vienna, Austria

    Sumit Deswal

Authors
  1. Anna Morath
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  2. Sumit Deswal
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  3. Wolfgang W. A. Schamel
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Corresponding author

Correspondence to Wolfgang W. A. Schamel .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Morath, A., Deswal, S., Schamel, W.W.A. (2018). CD3ζ. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_613

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