Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Anna Morath
  • Sumit Deswal
  • Wolfgang W. A. SchamelEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_613


 ζ;  CD247;  TCRζ


CD3ζ is a homodimer-forming type 1 transmembrane (TM) protein and is part of the T cell antigen receptor (TCR) complex along with TCRαβ, CD3γε, and CD3δε dimers expressed on the surface of T cells (Figs. 1 and 2). T cells are an important component of the vertebrate adaptive immune system that are activated via TCR by the peptides generated from infectious agents and presented on major histocompatibility complex (MHC) molecules on the surface of cells. CD3ζ possesses a small extracellular part, a TM region, and a long cytoplasmic part that contains three immunoreceptor tyrosine-based activation motifs (ITAMs), which correspond to the six tyrosines that get phosphorylated upon antigen binding to the extracellular part of TCRαβ. Phosphorylation subsequently activates several downstream signaling cascades. Hence, CD3ζ plays a vital role in the activation of a T cell. CD3ζ is also part of the pre-TCR in pre-T cells and the γδTCR in γδ T cells that...
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Anna Morath
    • 1
    • 2
    • 3
    • 4
  • Sumit Deswal
    • 1
    • 5
    • 6
  • Wolfgang W. A. Schamel
    • 1
    • 2
    • 3
    Email author
  1. 1.Department of Immunology, Institute for Biology IIIUniversity of FreiburgFreiburgGermany
  2. 2.Centre for Biological Signaling Studies (BIOSS)University of FreiburgFreiburgGermany
  3. 3.Centre of Chronic Immunodeficiency (CCI)University Medical Center Freiburg and University of FreiburgFreiburgGermany
  4. 4.Spemann Graduate School of Biology and MedicineUniversity of FreiburgFreiburgGermany
  5. 5.Max Planck Institute of ImmunobiologyFreiburgGermany
  6. 6.Research Institute of Molecular PathologyViennaAustria