Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

ADAP1

  • Benjamin J. Gosney
  • Christian R. Robinson
  • Venkateswarlu Kanamarlapudi
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_609

Synonyms

Historical Background

ADAP1 (ADP-ribosylation factor [ARF] GTPase activating protein [GAP] with dual pleckstrin homology (PH) domains 1) was initially characterized from pig cerebellum and identified as a 42 kDa protein that binds with high affinity to phosphatidylinositol (3,4,5)-triphosphate (PIP 3) or its inositol head group, inositol 1,3,4,5-tetrakisphosphate (IP 4) (Reiser et al. 1991). Hence, it was originally named PIP 3/IP 4-binding protein (PIP3BP/p42IP4) and has also been called Centaurin-α1 (Hammonds-Odie et al. 1996; Stricker et al. 1997; Tanaka et al. 1999). It has been renamed ADAP1, which more accurately describe the structure and function of this protein (Kahn et al. 2008). The membrane lipid PIP 3 and the water-soluble ligand IP 4both serve as signal transducers that link extracellular stimuli to numerous intracellular signaling cascades required for cell...
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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Benjamin J. Gosney
    • 1
  • Christian R. Robinson
    • 1
    • 2
  • Venkateswarlu Kanamarlapudi
    • 1
  1. 1.Institute of Life Science 1, School of MedicineSwansea UniversitySwanseaUK
  2. 2.Calon Cardio-Technology Ltd, Institute of Life Science 2Medical School, Swansea UniversitySwanseaUK