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Encyclopedia of Signaling Molecules pp 156–164Cite as

ADAP1

  • Reference work entry
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Synonyms

ARF GAP with dual pleckstrin homology (PH) domains; CENTA1; Centaurin alpha; GC1L; GCS1L; p42IP4; PIPBP

Historical Background

ADAP1 (ADP-ribosylation factor [ARF] GTPase activating protein [GAP] with dual pleckstrin homology (PH) domains 1) was initially characterized from pig cerebellum and identified as a 42 kDa protein that binds with high affinity to phosphatidylinositol (3,4,5)-triphosphate (PIP3) or its inositol head group, inositol 1,3,4,5-tetrakisphosphate (IP4) (Reiser et al. 1991). Hence, it was originally named PIP3/IP4-binding protein (PIP3BP/p42IP4) and has also been called Centaurin-α1 (Hammonds-Odie et al. 1996; Stricker et al. 1997; Tanaka et al. 1999). It has been renamed ADAP1, which more accurately describe the structure and function of this protein (Kahn et al. 2008). The membrane lipid PIP3 and the water-soluble ligand IP4both serve as signal transducers that link extracellular stimuli to numerous intracellular signaling cascades required for cell...

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Author information

Authors and Affiliations

  1. Institute of Life Science 1, School of Medicine, Swansea University, Singleton Park, SA2 8PP, Swansea, Wales, UK

    Benjamin J. Gosney, Christian R. Robinson & Venkateswarlu Kanamarlapudi

  2. Calon Cardio-Technology Ltd, Institute of Life Science 2, Medical School, Swansea University, Swansea, Wales, UK

    Christian R. Robinson

Authors
  1. Benjamin J. Gosney
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  2. Christian R. Robinson
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  3. Venkateswarlu Kanamarlapudi
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Corresponding author

Correspondence to Venkateswarlu Kanamarlapudi .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Gosney, B.J., Robinson, C.R., Kanamarlapudi, V. (2018). ADAP1. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_609

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