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HPK1

  • Reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 182 Accesses

Synonyms

Hematopoietic progenitor kinase 1; Map 4k1; Mitogen-activated protein kinase kinase kinase kinase 1

Historical Background

Since 1996, when hematopoietic progenitor kinase 1 (HPK1) was first described as an activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) pathway (Kiefer et al. 1996), a range of information concerning activation, subcellular localization, putative interaction partners, and the regulatory function of HPK1 in immune cells was gathered. The initial studies showed that while HPK1 mRNA is ubiquitously detectable in embryonic tissues, expression in the adult is restricted to hematopoietic organs like thymus, bone marrow, and spleen. Protein database sequence comparison classified HPK1 as a member of the Ste20-related protein kinase family and is most closely related to the germinal center kinase (GCK), a MAP 4 kinase. The structure of HPK1 comprises an N-terminal kinase domain, a central region containing proline-rich (SH3-binding)...

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References

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Authors and Affiliations

  1. Department Vascular Cell Biology, Max Planck Institute for Molecular Biomedicine, Mammalian Cell Signaling Laboratory, Münster, Germany

    Sebastian Königsberger & Friedemann Kiefer

Authors
  1. Sebastian Königsberger
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  2. Friedemann Kiefer
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Correspondence to Friedemann Kiefer .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Königsberger, S., Kiefer, F. (2018). HPK1. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_602

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