Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Sebastian Königsberger
  • Friedemann KieferEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_602


Historical Background

Since 1996, when hematopoietic progenitor kinase 1 (HPK1) was first described as an activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) pathway (Kiefer et al. 1996), a range of information concerning activation, subcellular localization, putative interaction partners, and the regulatory function of HPK1 in immune cells was gathered. The initial studies showed that while HPK1 mRNA is ubiquitously detectable in embryonic tissues, expression in the adult is restricted to hematopoietic organs like thymus, bone marrow, and spleen. Protein database sequence comparison classified HPK1 as a member of the Ste20-related protein kinase family and is most closely related to the germinal center kinase (GCK), a MAP 4 kinase. The structure of HPK1 comprises an N-terminal kinase domain, a central region containing proline-rich...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department Vascular Cell Biology, Max Planck Institute for Molecular BiomedicineMammalian Cell Signaling LaboratoryMünsterGermany