Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Inhibitor of Apoptosis (IAP) Proteins

  • Mads Gyrd-Hansen
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_595

Historical Background

Inhibitor of apoptosis (IAP) proteins were identified in 1993 in a cDNA-based screen for baculovirus genes that prevent the induction of apoptosis in Spodoptera frugiperda SF-21 insect cells after viral infection (Crook et al. 1993). iap genes were found in other baculoviruses, and further analysis of these IAP proteins led to the identification of their functional domains, namely, two baculovirus IAP repeat (BIR) domains and a C-terminal C3HC4-type Zn-finger, which is now known to be a really interesting new gene (RING) domain (Vaux and Silke 2005) (Fig. 1).
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Novo Nordisk Foundation Center for Protein ResearchUniversity of CopenhagenCopenhagenDenmark