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Inhibitor of Apoptosis (IAP) Proteins

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Encyclopedia of Signaling Molecules

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Historical Background

Inhibitor of apoptosis (IAP) proteins were identified in 1993 in a cDNA-based screen for baculovirus genes that prevent the induction of apoptosis in Spodoptera frugiperda SF-21 insect cells after viral infection (Crook et al. 1993). iap genes were found in other baculoviruses, and further analysis of these IAP proteins led to the identification of their functional domains, namely, two baculovirus IAP repeat (BIR) domains and a C-terminal C3HC4-type Zn-finger, which is now known to be a really interesting new gene (RING) domain (Vaux and Silke 2005) (Fig. 1).

Inhibitor of Apoptosis (IAP) Proteins, Fig. 1
figure 1027 figure 1027

Schematic representation of IAP proteins. The number of residues in each IAP as well as the functional motifs that they contain is shown. NAIP, survivin, BRUCE, ILP2, and ML-IAP are shown in this figure, but are not discussed in detail. In addition to DIAP1 and DIAP2, orthologues of survivin and BRUCE are also encoded in the genome of fruit flies (Drosophila...

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Authors and Affiliations

  1. Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, 2200, Copenhagen, Denmark

    Mads Gyrd-Hansen

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  1. Mads Gyrd-Hansen
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Correspondence to Mads Gyrd-Hansen .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Gyrd-Hansen, M. (2018). Inhibitor of Apoptosis (IAP) Proteins. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_595

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