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Cdc7

  • Reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 142 Accesses

Synonyms

Cdc7 (S. cerevisiae); Cdc7L1; Hsk1 (homologue of Cdc7 [seven] kinase, S. pombe); Spo4 (second Cdc7 homologue in S. pombe)

Historical Background

Cdc7 was originally discovered as a temperature-sensitive mutant of budding yeast defective in progression of cell cycle (Hartwell 1973). The growth of cdc7(ts) is arrested immediately before the onset of the S phase at a nonpermissive temperature. Upon return to a permissive temperature, cells resume growth and can complete S phase in the absence of ongoing protein synthesis. This led to the notion that Cdc7 is required for DNA replication at the stage where all other proteins required for DNA synthesis are prepared. Cdc7 was later cloned and was identified as encoding a serine/threonine kinase (Hollingsworth and Sclafani 1990). Dbf4, another cell cycle regulator required at the onset of the S phase, was then shown to encode an activation subunit for Cdc7. An ortholog of Cdc7 was first identified in fission yeast (Hsk1; (Masai et al. 1995...

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Authors and Affiliations

  1. Genome Dynamics Project, Department of Genome Medicine, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, 156-8506, Tokyo, Japan

    Hisao Masai

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  1. Hisao Masai
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Correspondence to Hisao Masai .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Masai, H. (2018). Cdc7. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_593

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