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G Protein Alpha Transducin

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References

  • Allen AE, Cameron MA, Brown TM, Vugler AA, Lucas RJ. Visual responses in mice lacking critical components of all known retinal phototransduction cascades. PLoS One. 2010;5:e15063.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Artemyev NO. Light-dependent compartmentalization of transducin in rod photoreceptors. Mol Neurobiol. 2008;37:44–51.

    Article  PubMed  CAS  Google Scholar 

  • Bitensky MW, Miki N, Keirns JJ, Keirns M, Baraban JM, Freeman J, Wheeler MA, Lacy J, Marcus FR. Activation of photoreceptor disk membrane phosphodiesterase by light and ATP. Adv Cyclic Nucleotide Res. 1975;5:213–40.

    PubMed  CAS  Google Scholar 

  • Bourne HR. G-proteins and GPCRs: from the beginning. Ernst Schering Found Symp Proc. 2006;2:1–21.

    Google Scholar 

  • Calvert PD, Krasnoperova NV, Lyubarsky AL, Isayama T, Nicoló M, Kosaras B, Wong G, Gannon KS, Margolskee RF, Sidman RL, Pugh Jr EN, Makino CL, Lem J. Phototransduction in transgenic mice after targeted deletion of the rod transducin alpha-subunit. Proc Natl Acad Sci USA. 2000;97:13913–8.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Chen CK, Burns ME, He W, Wensel TG, Baylor DA, Simon MI. Slowed recovery of rod photoresponse in mice lacking the GTPase accelerating protein RGS9-1. Nature. 2000;403:557–60.

    Article  PubMed  CAS  Google Scholar 

  • Chen CK, Woodruff ML, Chen FS, Shim H, Cilluffo MC, Fain GL. Replacing the rod with the cone transducin subunit decreases sensitivity and accelerates response decay. J Physiol. 2010;588:3231–41.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Fu Y, Yau KW. Phototransduction in mouse rods and cones. Pflugers Arch. 2007;454:805–19.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Fung BK, Hurley JB, Stryer L. Flow of information in the light-triggered cyclic nucleotide cascade of vision. Proc Natl Acad Sci USA. 1981;78:152–6.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Godchaux 3rd W, Zimmerman WF. Membrane-dependent guanine nucleotide binding and GTPase activities of soluble protein from bovine rod cell outer segments. J Biol Chem. 1979;254:7874–84.

    PubMed  CAS  Google Scholar 

  • Keresztes G, Martemyanov KA, Krispel CM, Mutai H, Yoo PJ, Maison SF, Burns ME, Arshavsky VY, Heller S. Absence of the RGS9.Gbeta5 GTPase-activating complex in photoreceptors of the R9AP knockout mouse. J Biol Chem. 2004;279:1581–4.

    Article  PubMed  Google Scholar 

  • Krispel CM, Chen CK, Simon MI, Burns ME. Prolonged photoresponses and defective adaptation in rods of Gbeta5-/- mice. J Neurosci. 2003;23:6965–71.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Krispel CM, Chen D, Melling N, Chen YJ, Martemyanov KA, Quillinan N, Arshavsky VY, Wensel TG, Chen CK, Burns ME. RGS expression rate-limits recovery of rod photoresponses. Neuron. 2006;51:409–16.

    Article  PubMed  CAS  Google Scholar 

  • Lobanova ES, Herrmann R, Finkelstein S, Reidel B, Skiba NP, Deng WT, Jo R, Weiss ER, Hauswirth WW, Arshavsky VY. Mechanistic basis for the failure of cone transducin to translocate: why cones are never blinded by light. J Neurosci. 2010;30:6815–24.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Luo DG, Xue T, Yau KW. How vision begins: an odyssey. Proc Natl Acad Sci USA. 2008;105:9855–62.

    Article  PubMed  PubMed Central  Google Scholar 

  • Slepak VZ, Hurley JB. Mechanism of light-induced translocation of arrestin and transducin in photoreceptors: interaction-restricted diffusion. IUBMB Life. 2008;60:2–9.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Vuong TM, Chabre M, Stryer L. Millisecond activation of transducin in the cyclic nucleotide cascade of vision. Nature. 1984;311:659–61.

    Article  PubMed  CAS  Google Scholar 

  • Wheeler GL, Bitensky MW. A light-activated GTPase in vertebrate photoreceptors: regulation of light-activated cyclic GMP phosphodiesterase. Proc Natl Acad Sci USA. 1977;74:4238–42.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Yee R, Liebman PA. Light-activated phosphodiesterase of the rod outer segment. Kinetics and parameters of activation and deactivation. J Biol Chem. 1978;253:8902–9.

    PubMed  CAS  Google Scholar 

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Correspondence to Ching-Kang Chen .

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Shim, H., Chen, CK. (2018). G Protein Alpha Transducin. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_587

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