Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Cholecystokinin-2 Receptor

  • Jean MorissetEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_582


Historical Background

With the availability of modern biochemical and molecular techniques developed in the 1980s and 1990s, it was possible to characterize and clone the two cholecystokinin receptors known today. They are now identified as the cholecystokinin-1 (CCK-1) and the cholecystokinin-2 (CCK-2) receptor subtypes.

In this review entry, we will summarize what we now know about the CCK-2 receptor. More specifically, we will discuss its biochemical characterization, its organ localization, its functions in normal organs, its role in cancer along with the intracellular signaling routes used to relay its messages. References to the other cholecystokinin receptor are given in the preceding chapter.

Biochemical Characterization

Initially, the CCK-1 receptor was known as the CCKA receptor (A for alimentary) and the CCK-2 receptor as the CCKBreceptor (B for brain). This reclassification of the CCK receptor subtypes occurred recently based on...

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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Service de gastroentérologie, Département de médecineUniversité de SherbrookeSherbrookeCanada