Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Carlos Eduardo Repeke
  • Thiago Pompermaier Garlet
  • Carolina Favaro Francisconi
  • Daiana Broll
  • Ana Paula Favaro Trombone
  • Gustavo Pompermaier GarletEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_579


Historical Background

CCL3 was initially described in 1988, as a partially purified 8-kDa protein doublet from conditioned medium of endotoxin-stimulated mouse macrophages. In the view of its prominent proinflammatory chemotactic role, characterized both in vivo and in vitro at that time, this protein was denominated “macrophage inflammatory protein-1 alpha” (MIP-1α). Subsequently, a high nucleotide sequence similarity (69%) was found between the murine MIP-1α cDNA and a reported human cDNA cloned from stimulated lymphocytes, initially called LD78α or GOS19, assuming to be the human counterpart to murine MIP-1α (Wolpe et al. 1988; Menten et al. 2002; Maurer and von Stebut 2004). Interestingly, human and murine MIP-1α have been independently isolated in many laboratories in relatively short time span and has been named differently by each group. Similarly, several other cytokines with chemotactic abilities were identified, leading to...

This is a preview of subscription content, log in to check access.


  1. Bianchi R, Kastrisianaki E, Giambanco I, Donato R. S100B protein stimulates microglia migration via rage-dependent up-regulation of chemokine expression and release. J Biol Chem. 2011;286(9):7214–26.PubMedPubMedCentralCrossRefGoogle Scholar
  2. Carrington M, Dean M, Martin MP, O'Brien SJ. Genetics of HIV-1 infection: chemokine receptor CCR5 polymorphism and its consequences. Hum Mol Genet. 1999;8(10):1939–45.PubMedCrossRefGoogle Scholar
  3. Cheng JF, Jack R. CCR1 antagonists. Mol Divers. 2008;12(1):17–23.PubMedCrossRefGoogle Scholar
  4. Cook DN. The role of MIP-1 alpha in inflammation and hematopoiesis. J Leukoc Biol. 1996;59(1):61–6.PubMedCrossRefGoogle Scholar
  5. Hirashima M, Ono T, Nakao M, Nishi H, Kimura A, Nomiyama H, et al. Nucleotide sequence of the third cytokine LD78 gene and mapping of all three LD78 gene loci to human chromosome 17. DNA Seq. 1992;3(4):203–12.PubMedCrossRefGoogle Scholar
  6. Horuk R. Chemokine receptors. Cytokine Growth Factor Rev. 2001;12(4):313–35.PubMedCrossRefGoogle Scholar
  7. Kanegasaki S, Tsuchiya T. Alarmins released during local antitumor treatments play an essential role in enhancing tumor growth inhibition at treated and non-treated sites via a derivative of CCL3. Oncoimmunology. 2014;3(10):e958965-1-3.CrossRefGoogle Scholar
  8. Lahrtz F, Piali L, Spanaus KS, Seebach J, Fontana A. Chemokines and chemotaxis of leukocytes in infectious meningitis. J Neuroimmunol. 1998;85(1):33–43.PubMedCrossRefGoogle Scholar
  9. Machado FS, Koyama NS, Carregaro V, Ferreira BR, Milanezi CM, Teixeira MM, et al. CCR5 plays a critical role in the development of myocarditis and host protection in mice infected with Trypanosoma cruzi. J Infect Dis. 2005;191(4):627–36.PubMedCrossRefGoogle Scholar
  10. Maurer M, von Stebut E. Macrophage inflammatory protein-1. Int J Biochem Cell Biol. 2004;36(10):1882–6.PubMedCrossRefGoogle Scholar
  11. Menten P, Wuyts A, Van Damme J. Macrophage inflammatory protein-1. Cytokine Growth Factor Rev. 2002;13(6):455–81.PubMedCrossRefGoogle Scholar
  12. Neote K, DiGregorio D, Mak JY, Horuk R, Schall TJ. Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor. Cell. 1993;72(3):415–25.PubMedCrossRefGoogle Scholar
  13. Patel DD, Zachariah JP, Whichard LP. CXCR3 and CCR5 ligands in rheumatoid arthritis synovium. Clin Immunol. 2001;98(1):39–45. OrlandoPubMedCrossRefGoogle Scholar
  14. Patterson SJ, Pesenacker AM, Wang AY, Gillies J, Mojibian M, Morishita K, et al. T regulatory cell chemokine production mediates pathogenic T cell attraction and suppression. J Clin Invest. 2016;126(3):1039–51.PubMedPubMedCentralCrossRefGoogle Scholar
  15. Proudfoot AE, Power CA, Rommel C, Wells TN. Strategies for chemokine antagonists as therapeutics. Semin Immunol. 2003;15(1):57–65.PubMedCrossRefGoogle Scholar
  16. Repeke CE, Ferreira Jr SB, Claudino M, Silveira EM, de Assis GF, Avila-Campos MJ, et al. Evidences of the cooperative role of the chemokines CCL3, CCL4 and CCL5 and its receptors CCR1+ and CCR5+ in RANKL + cell migration throughout experimental periodontitis in mice. Bone. 2010;46(4):1122–30.PubMedCrossRefGoogle Scholar
  17. Rollins BJ. Chemokines. Blood. 1997;90(3):909–28.PubMedPubMedCentralGoogle Scholar
  18. Samson M, Labbe O, Mollereau C, Vassart G, Parmentier M. Molecular cloning and functional expression of a new human CC-chemokine receptor gene. Biochemistry. 1996;35(11):3362–7.PubMedCrossRefGoogle Scholar
  19. Segerer S, Nelson PJ, Schlondorff D. Chemokines, chemokine receptors, and renal disease: from basic science to pathophysiologic and therapeutic studies. J Am Soc Nephrol. 2000;11(1):152–76.PubMedPubMedCentralGoogle Scholar
  20. Silva TA, Garlet GP, Fukada SY, Silva JS, Cunha FQ. Chemokines in oral inflammatory diseases: apical periodontitis and periodontal disease. J Dent Res. 2007;86(4):306–19.PubMedCrossRefGoogle Scholar
  21. Walker WE, Kurscheid S, Joshi S, Lopez CA, Goh G, Choi M, et al. Increased levels of macrophage inflammatory proteins result in resistance to R5-Tropic HIV-1 in a subset of elite controllers. J Virol. 2015;89(10):5502–14.PubMedPubMedCentralCrossRefGoogle Scholar
  22. Wolpe SD, Davatelis G, Sherry B, Beutler B, Hesse DG, Nguyen HT, et al. Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties. J Exp Med. 1988;167(2):570–81.PubMedCrossRefGoogle Scholar
  23. Zlotnik A, Yoshie O. Chemokines: a new classification system and their role in immunity. Immunity. 2000;12(2):121–7.PubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Carlos Eduardo Repeke
    • 1
  • Thiago Pompermaier Garlet
    • 2
  • Carolina Favaro Francisconi
    • 3
  • Daiana Broll
    • 4
  • Ana Paula Favaro Trombone
    • 5
  • Gustavo Pompermaier Garlet
    • 3
    Email author
  1. 1.PPGCAS Lab, Department of Dentistry of LagartoFederal University of Sergipe – DOL/UFSLagartoBrazil
  2. 2.Department of Structural and Molecular Biology and GeneticsState University of Ponta GrossaPonta GrossaBrazil
  3. 3.OSTEOimmunology lab, Department of Biological Sciences, School of Dentistry of BauruSão Paulo University, FOB/USPBauruBrazil
  4. 4.PPGCSFederal Unversity of SergipeSão CristóvãoBrazil
  5. 5.Universidade do Sagrado Coração (USC)BauruBrazil