Historical Background
Mammalian VRK (vaccinia-related kinases) were originally identified as two human EST, VRK1 and VRK2, expressed in proliferating cell lines and regenerating liver. These EST have homology to the catalytic region of the B1R kinase of vaccinia virus (Nezu et al. 1997) that is expressed early in viral infection and is required for viral DNA replication. These VRK proteins were classified as a new group of Ser-Thr kinases in the human kinome diverging very early from the same branch that led to casein kinase I (CK1) (Manning et al. 2002). This family has only one ortholog gene in invertebrates, such as C. elegans and Drosophila melanogaster, and is not present in yeast (Klerkx et al. 2009).
VRK2 Gene and Expression
The human VRK2gene is located in chromosome 2p16.1 and generates two messages by alternative splicing. Their translation generates two protein isoforms, VRK2A (also known as...
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Monsalve, D.M., Blanco, S., Fernández, I.F., Vázquez-Cedeira, M., Lazo, P.A. (2018). VRK2. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_562
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DOI: https://doi.org/10.1007/978-3-319-67199-4_562
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