VRK proteins were identified as two human EST sequences whose translation products have homology with the kinase domain of the unique vaccinia virus B1 kinase, from where its name is derived. During its evolution and adaptation to its host, the virus incorporated the cellular sequence required for viral life-cycle regulation. VRK1 is a chromatin kinase that regulates multiple processes, reflecting its late appearance in evolution as coordinator of preexisting functions in higher eukaryotes.
VRK1 Gene Structure and Expression
The human VRK1 gene is located on the chromosomal region 14q32.2, contains 12 exons and codes for a protein with 396 amino acids (Nichols and Traktman 2004). This gene has a polymorphism, marker rs722869, which is useful in the identification of population structure and genetic ancestry (Lao et al. 2006). Chromosomal translocations in this region do not affect...
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