DARPP-32; Darpp32; Dopamine and adenosine 3′,5′-monophosphate-regulated phosphoprotein, 32 kDa; Dopamine and cAMP-regulated phosphoprotein; Dopamine- and cAMP-regulated phosphoprotein, Mr32 kDa; Ppp1r1b; Protein phosphatase 1 DARPP-32 inhibitor protein; Protein phosphatase 1, regulatory (inhibitor) subunit 1B
Protein phosphorylation is one of the most important posttranslational events that regulate myriad of biological processes such as cell division, cell differentiation, metabolism and modulation of signal transduction pathways (Ubersax and Ferrell 2007).
Studies using behavioral analysis of animal models suggest that alterations in critical intracellular signaling pathways have an important role in the pathophysiology and treatment of complex neuropsychiatric disorders. The hypothesis is that if the vast majority of psychiatric medications exert their primary therapeutic actions in the first week of treatment, the therapeutic effects involve...
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