Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Sofia Nolasco
  • João Gonçalves
  • Helena SoaresEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_550


 Cct1;  TCP-1

Historical Background

In the cell, the correct folding of many proteins depends on the function of preexisting ones known as molecular chaperones (for a review see Hartl and Hayer-Hartl 2009). These, were defined as proteins that bind to and stabilize an otherwise unstable conformation of another protein, and by controlling binding and release, facilitate its correct fate in vivo, be it folding, oligomeric assembly, transport to a particular subcellular compartment, or disposal by degradation. Molecular chaperones do not convey steric information specifying correct folding: instead, they prevent incorrect interactions within and between nonnative peptides, thus typically increasing the yield but not the rate of folding reactions.

Molecular chaperones are ubiquitous and comprise several protein families that are structurally unrelated (Hartl and Hayer-Hartl 2009). The Hsp70s and the Chaperonin families have been extensively studied. Hsp70homologs are widespread...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Sofia Nolasco
    • 1
    • 2
    • 3
    • 4
  • João Gonçalves
    • 5
    • 6
  • Helena Soares
    • 1
    • 3
    Email author
  1. 1.Departamento de Química e Bioquímica, Centro de Química e Bioquímica, Faculdade de CiênciasUniversidade de LisboaLisboaPortugal
  2. 2.Instituto Gulbenkian de CiênciaOeirasPortugal
  3. 3.Escola Superior de Tecnologia da Saúde de LisboaLisboaPortugal
  4. 4.Centro de Investigação Interdisciplinar em Sanidade Animal, Faculdade de Medicina VeterináriaUniversidade de LisboaLisboaPortugal
  5. 5.Centro de Química e Bioquímica, Faculdade de Ciências, Universidade de LisboaLisboaPortugal
  6. 6.Lunenfeld-Tanenbaum Research InstituteTorontoCanada