Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Guanylyl Cyclase C

  • Vishwas Mishra
  • Somesh Nandi
  • Sandhya S. VisweswariahEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_539



Historical Background

Guanylyl cyclase C (GC-C) is the target for a family of heat-stable enterotoxins (ST) produced by enterotoxigenic Escherichia coli (ETEC), Vibrio cholera non-01, and Yersinia enterocolitica. Stable toxin-mediated diarrheas are observed frequently in infants and contribute significantly to incidences of Travelers’ Diarrhea. Early studies demonstrated that the effects of ST were mediated by increases in intracellular cGMP levels in intestinal cells, and the receptor for ST was almost exclusively expressed in the apical microvillar compartment of the intestinal brush-border epithelia (De Jonge 1975; Schulz et al. 1990). Subsequently, the receptor for ST peptides was identified as a member of the membrane-associated guanylyl cyclase family, and binding of ST to GC-C led to activation of the receptor, resulting in the production and accumulation of cGMP in enterocytes (Schulz et al. 1990). Effectors of cGMP in intestinal cells...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Vishwas Mishra
    • 1
  • Somesh Nandi
    • 1
  • Sandhya S. Visweswariah
    • 1
    Email author
  1. 1.Department of Molecular Reproduction, Development and GeneticsIndian Institute of ScienceBangaloreIndia