Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

NMT (N-Myristoyltransferase)

  • Umashankar Das
  • Joel Howlett
  • Sujeet Kumar
  • Sreejit Parameswaran
  • Anil Sharma
  • Jonathan R. Dimmock
  • Rajendra K. SharmaEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_538


Historical Background

Lipid modification is one of the most common posttranslational modifications in eukaryotic cells that take place either at or near the amino terminus or the carboxy terminus of the proteins (Resh 2013). This process is sequence specific and classified as myristoylation, palmitoylation, prenylation, and glycosylphosphatidylinositol according to the identity of the attached lipid. The structural changes resulting from these modifications have effects on the stability, cellular location, and biological activity of the proteins (Resh 2013). These processes are becoming increasingly important for the study of cancer, as several key oncoproteins require this type of “posttranslational maturation” for their biological activity and for their ability to transform cells. Among these lipid modifications, protein myristoylation is known to be very important which refers to the covalent...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Umashankar Das
    • 1
  • Joel Howlett
    • 2
  • Sujeet Kumar
    • 2
  • Sreejit Parameswaran
    • 2
  • Anil Sharma
    • 3
  • Jonathan R. Dimmock
    • 1
  • Rajendra K. Sharma
    • 2
    • 4
    Email author
  1. 1.Drug Discovery and Development Research Group, College of Pharmacy and NutritionUniversity of SaskatchewanSaskatoonCanada
  2. 2.Department of Pathology and Laboratory Medicine, College of MedicineUniversity of SaskatchewanSaskatoonCanada
  3. 3.ENT clinicSaskatoonCanada
  4. 4.Cancer Research Unit, Saskatchewan Cancer AgencySaskatoonCanada