Historical Background
Prior to 2008, there were no publications on the TMEM85 gene or protein. The GenBank and Entrez Gene databases described TMEM85 as an evolutionary conserved transmembrane domain containing protein (DUF1077 superfamily motif) found in all eukaryotes examined (TMEM85 (Transmembrane Protein 85)). In the yeast Saccharomyces cerevisiae, the TMEM85 orthologue is called YGL231c. In 2003, it was reported that yeast cells lacking YGL231c showed an increased sensitivity to the toxic effects of ectopically expressed Parkinson’s disease associated gene α-synuclein (Willingham et al. 2003). Finally, the analysis of a GFP tagged genomic copy of YGL231c suggests that the protein is a resident of the endoplasmic reticulum (ER) (YGL231c-gene).
TMEM85, An Anti-Apoptotic Gene
By screening a human heart cDNA expression library in yeast cell undergoing apoptosis due to the ectopic expression of a cDNA...
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Bossers K, Meerhoff G, Balesar R, van Dongen JW, Kruse CG, Swaab DF, Verhaagen J. Analysis of gene expression in Parkinson’s disease: possible involvement of neurotrophic support and axon guidance in dopaminergic cell death. Brain Pathol. 2009;19:91–107.
Greenwood MT, Ludovico P. Expressing and functional analysis of mammalian apoptotic regulators in yeast. Cell Death Differ. 2010;17:737–45.
Jonikas MC, Collins SR, Denic V, Oh E, Quan EM, Schmid V, Weibezahn J, Schwappach B, Walter P, Weissman JS, Schuldiner M. Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum. Science. 2009;323:1693–7.
Ring G, Khoury CM, Solar AJ, Yang Z, Mandato CA, Greenwood MT. Transmembrane protein 85 from both human (TMEM85) and yeast (YGL231c) inhibit hydrogen peroxide mediated cell death in yeast. FEBS Lett. 2008;582:2637–42.
Saccharomyces Genome Database for the YGL231c gene. http://www.yeastgenomeorg/cgi-bin/locusfpl?locus=YGL231C. Accessed 5 April 2011.
The Entez Gene web page for the TMEM85 gene. http://www.ncbinlmnihgov/gene/51234. Accessed 5 April 2011.
The Universal Protein Resource (UniProt) web page for the human TMM85 protein http://www.uniprot.org/uniprot/Q5J8M3. Accessed 5 April 2011.
Willingham S, Outeiro TF, DeVit MJ, Lindquist SL, Muchowski PJ. Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein. Science. 2003;302:1769–72.
Yan Z, Lathia KB, Clapshaw PA. Murine spinal cord transcriptome analysis following reduction of prevalent myelin cDNA sequences. Cell Mol Neurobiol. 2009;29:1109–19.
Zheng J, Anderson CT, Miller KK, Cheatham M, Dallos P. Identifying components of the hair-cell interactome involved in cochlear amplification. BMC Genomics. 2009;10:127.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG
About this entry
Cite this entry
Greenwood, M.T. (2018). TMEM85 (Transmembrane Protein 85). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_532
Download citation
DOI: https://doi.org/10.1007/978-3-319-67199-4_532
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-67198-7
Online ISBN: 978-3-319-67199-4
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences