Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Myosin I (Myo1)

  • Lynne M. ColuccioEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_529


The nomenclature of myosins I is confusing, although there is general agreement in the naming of myosins I in vertebrates (Gillespie et al. 2001). The names used in vertebrates, however, do not correspond to those used in lower organisms. The following names have been used to refer to class I myosins:

In yeast: Myo3, Myo5

In Acanthamoeba: Myosin IA-C

In Dictyostelium: MyoA-F, K

In Caenorhabditis elegans: Myo1A or HUM-1; HUM-5

In Drosophila: Myo1A (Myo31DF, CG7438); Myo1B (Myo61F, CG9155)

In vertebrates: Myo1a-h; (MyoA-H in humans)
  • Myo1a (Brush border myosin I, 110-kDa-calmodulin complex)

  • Myo1b (myr 1, myosin-Iα, 130-kDa myosin I)

  • Myo1c (myr 2, myosin-Ιβ,110-kDa myosin I)

  • Myo1d (myr 4, myosin-Iγ, 105-kDa myosin I)

  • Myo1e (myr 3, human myosin-1C)

  • Myo1f

  • Myo1g

  • Myo1h

Historical Background

Myosin 1 is the largest of ∼35 different classes of proteins that comprise the myosin superfamily, a collection of actin-associated molecular motor proteins that use the energy from ATP...

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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Boston Biomedical Research InstituteWatertownUSA