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Beta-Catenin

  • Reference work entry
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Encyclopedia of Signaling Molecules

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Synonyms

Catenin (cadherin-associated protein), beta 1 (88kD); Catenin beta; Catnb; Ctnnb; CTNNB1

Historical Background

Beta-catenin (β-catenin) (Armadillo in Drosophila) is a multifunctional protein involved in two essential cellular events: cell–cell adhesion and the canonical Wnt signaling pathway (Takemaru 2006). β-Catenin/armadillo (Arm) was initially identified as a segment polarity protein in Drosophila in the early 1980s, and later recognized as a key downstream effector of the Wnt pathway. Meanwhile, β-catenin was shown to be an integral component of cadherin-mediated cell adhesion complexes. Over the past two decades, interdisciplinary research has tremendously advanced our knowledge of β-catenin function and its involvement in human disorders (Takemaru et al. 2008; Cadigan and Peifer 2009; MacDonald et al. 2009). At cell–cell adhesion junctions, β-catenin interacts with type-I cadherins and α-catenin, which in turn associates with the actin cytoskeleton. In canonical Wnt...

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Author information

Authors and Affiliations

  1. Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, 11794, USA

    Ken-Ichi Takemaru, Xingwang Chen & Feng-Qian Li

Authors
  1. Ken-Ichi Takemaru
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  2. Xingwang Chen
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  3. Feng-Qian Li
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Corresponding author

Correspondence to Ken-Ichi Takemaru .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Takemaru, KI., Chen, X., Li, FQ. (2018). Beta-Catenin. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_528

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