Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

RGS Protein Family

  • David P. SiderovskiEmail author
  • Adam J. Kimple
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_527


Historical Background

Signal transduction by G protein–coupled receptors (GPCRs) was considered for many years (Gilman 1987) to be a three-component system: the cell-surface receptor to receive external input from hormones and neurotransmitters, the heterotrimeric G protein to transduce this input to the intracellular compartment by its structural changes upon the exchange of guanosine triphosphate (GTP) for guanosine diphosphate (GDP), and effector proteins (such as  adenylyl cyclase, phospholipase C, and ion channels) to propagate the signal forward as changes in cell membrane potential and/or intracellular second messenger levels. However, for many physiological responses mediated by GPCRs, including the visual response controlled by the photoreceptor, rhodopsin (Arshavsky and Pugh 1998), intracellular signaling was known to be far shorter in duration than the time observed for the isolated components to revert to...
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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of PharmacologyUniversity of North Carolina at Chapel HillChapel HillUSA