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Encyclopedia of Signaling Molecules pp 4657–4663Cite as

RGS Protein Family

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Synonyms

Gα GAPs; Regulators of G-protein signaling; RGS proteins

Historical Background

Signal transduction by G protein–coupled receptors (GPCRs) was considered for many years (Gilman 1987) to be a three-component system: the cell-surface receptor to receive external input from hormones and neurotransmitters, the heterotrimeric G protein to transduce this input to the intracellular compartment by its structural changes upon the exchange of guanosine triphosphate (GTP) for guanosine diphosphate (GDP), and effector proteins (such as adenylyl cyclase, phospholipase C, and ion channels) to propagate the signal forward as changes in cell membrane potential and/or intracellular second messenger levels. However, for many physiological responses mediated by GPCRs, including the visual response controlled by the photoreceptor, rhodopsin (Arshavsky and Pugh 1998), intracellular signaling was known to be far shorter in duration than the time observed for the isolated components to revert to...

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References

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Author information

Authors and Affiliations

  1. Department of Pharmacology, University of North Carolina at Chapel Hill, 120 Mason Farm Road, Suite 4073, Chapel Hill, NC, 27599-7365, USA

    David P. Siderovski & Adam J. Kimple

Authors
  1. David P. Siderovski
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  2. Adam J. Kimple
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Corresponding author

Correspondence to David P. Siderovski .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Siderovski, D.P., Kimple, A.J. (2018). RGS Protein Family. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_527

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