Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Adhesion GPCRs

  • Christiane KirchhoffEmail author
  • Ben Davies
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_526


Historical Background

Among the superfamily of G-protein-coupled receptors, the adhesion GPCRs form the second largest family with 33 members in humans (for review, see Bjarnadottir et al. 2007). They are also the most diverse and complex GPCR family, often encoded by very large genes with numerous introns, and comprising highly diverse and variable N-terminal extracellular regions. Despite a remarkable structural diversity and low sequence homology, hydropathy analysis and biochemical data suggest that the adhesion GPCRs share the structural hallmark of all GPCRs – a heptahelical conformation with extracellular N-terminus and intracellular C-terminus. Approximately 150 distinct orthologues have been identified in the animal kingdom to date. The name adhesion GPCRs emphasizes the presence of multiple motifs in their long extracellular N-termini predicting adhesive properties, such as cadherin-, laminin-, lectin-, epidermal growth factor-, olfactomedin-,...
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Andrology, Clinic for Dermatology and VenereologyUniversity Hospital Hamburg-EppendorfHamburgGermany
  2. 2.Wellcome Trust Centre for Human GeneticsUniversity of Oxford Roosevelt DriveOxfordUK