Skip to main content
Book cover

Encyclopedia of Signaling Molecules pp 893–905Cite as

CD43

Synonyms

Galactoglycoprotein; Leukosialin; Sialophorin

Historical Background

CD43, also called sialophorin or leukosialin, was first identified as a defective molecule of leukocytes and platelets of patients affected with the Wiskott–Aldrich syndrome, yet the molecule responsible for this immunodeficiency turned out to be WASP. It was thought that expression of this heavily glycosylated, mucin-type membrane protein was restricted to hematopoietic cells. However, recent advances in the field evidence that CD43 is present in non-lymphoid tissues, particularly tumor cells. Here we reviewed the most important features about this molecule, highlighting the recent advances that have contributed to our understanding of the roles of CD43.

Gene Expression and Protein Structure

CD43 is a type I cell surface glycoprotein abundantly expressed on almost all hematopoietic cells, except for erythrocytes and resting B cells. Although initially considered an immune cell molecule, recent reports...

This is a preview of subscription content, access via your institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/978-3-319-67199-4_523
  • Chapter length: 13 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
eBook
USD   5,499.99
Price excludes VAT (USA)
  • ISBN: 978-3-319-67199-4
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Hardcover Book
USD   7,499.99
Price excludes VAT (USA)
Learn about institutional subscriptions
CD43, Fig. 1
CD43, Fig. 2
CD43, Fig. 3

References

  • Aguilar-Delfin I, Fierro NA, Rosenstein Y. CD43. UCSD-nature molecule pages. 2006. doi:10.1038/mp.a000001.01.

    CrossRef  Google Scholar 

  • Alkhamesi NA, Roberts G, Ziprin P, Peck DH. Induction of proteases in peritoneal carcinomatosis, the role of ICAM-1/CD43 interaction. Biomark Insights. 2007;2:377–84.

    PubMed  PubMed Central  CrossRef  Google Scholar 

  • Allenspach EJ, Cullinan P, Tong J, Tang Q, Tesciuba AG, Cannon JL, et al. ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse. Immunity. 2001;15(5):739–50.

    PubMed  CrossRef  CAS  Google Scholar 

  • Amano J, Morimoto C, Irimura T. Intestinal epithelial cells express and secrete the CD43 glycoform that contains core 2 O-glycans. Microbes Infect. 2001;3(9):723–8.

    PubMed  CrossRef  CAS  Google Scholar 

  • Andersson CX, Fernandez-Rodriguez J, Laos S, Sikut R, Sikut A, Baeckstrom D, Hansson GC. CD43 has a functional NLS, interacts with beta-catenin, and affects gene expression. Biochem Biophys Res Commun. 2004;316(1):12–7.

    PubMed  CrossRef  CAS  Google Scholar 

  • Andersson CX, Fernandez-Rodriguez J, Laos S, Baeckstrom D, Haass C, Hansson GC. Shedding and γ-secretase-mediated intramembrane proteolysis of the mucin-type molecule CD43. Biochem J. 2005;387(Pt 2):377–84.

    PubMed  PubMed Central  CrossRef  CAS  Google Scholar 

  • Balikova A, Jääger K, Viil J, Maimets T, Kadaja-Saarepuu L. Leukocyte marker CD43 promotes cell growth in co-operation with β-catenin in non-hematopoietic cancer cells. Int J Oncol. 2012;41(1):299–309.

    PubMed  CAS  Google Scholar 

  • Barat C, Tremblay MJ. Engagement of CD43 enhances human immunodeficiency virus type 1 transcriptional activity and virus production that is induced upon TCR/CD3 stimulation. J Biol Chem. 2002;277(32):28714–28724. Epub 2002 Jun 3.

    PubMed  CrossRef  CAS  Google Scholar 

  • Bravo-Adame ME, Vera-Estrella R, Barkla BJ, Martínez-Campos C, Flores-Alcantar A, Ocelotl-Oviedo JP, et al. An alternative mode of CD43 signal transduction activates pro-survival pathways of T lymphocytes. Immunology. 2016. doi:10.1111/imm.12670.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  • Camacho-Concha N, Olivos-Ortiz A, Nuñez-Rivera A, Pedroza-Saavedra A, Gutierrez-Xicotencatl L, Rosenstein Y, et al. CD43 promotes cells transformation by preventing Merlin-mediated contact inhibition of growth. PLoS One. 2013;8(11):e80806. doi:10.1371/journal.pone.0080806. eCollection 2013.

    CrossRef  PubMed  PubMed Central  CAS  Google Scholar 

  • Campo M, Randhawa AK, Dunstan S, Farrar J, Caws M, Bang ND, et al. Common polymorphisms in the CD43 gene region are associated with tuberculosis disease and mortality. Am J Respir Cell Mol Biol. 2015;52(3):342–8. doi:10.1165/rcmb.2014-0114OC.

    CrossRef  PubMed  PubMed Central  CAS  Google Scholar 

  • Ford ML, Onami TM, Sperling AI, Ahmed R, Evavold BD. CD43 modulates severity and onset of experimental autoimmune encephalomyelitis. J Immunol. 2003;171(12):6527–33.

    PubMed  CrossRef  CAS  Google Scholar 

  • Fratazzi C, Manjunath N, Arbeit RD, Carini C, Gerken TA, Ardman B, et al. A macrophage invasion mechanism for mycobacteria implicating the extracellular domain of CD43. J Exp Med. 2000;192(2):183–92.

    PubMed  PubMed Central  CrossRef  CAS  Google Scholar 

  • Freire-de-Lima L, Alisson-Silva F, Carvalho ST, Takiya CM, Rodrigues MM, DosReis GA, et al. Trypanosoma cruzi subverts host cell sialylation and may compromise antigen-specific CD8+ T cell responses. J Biol Chem. 2010;285(18):13388–96.

    PubMed  PubMed Central  CrossRef  CAS  Google Scholar 

  • Fu Q, Cash SE, Andersen JJ, Kennedy CR, Oldenburg DG, Zander VB, et al. CD43 in the nucleus and cytoplasm of lung cancer is a potential therapeutic target. Int J Cancer. 2013;132(8):1761–70. doi:10.1002/ijc.27873. Epub 2012 Oct 29.

    CrossRef  PubMed  CAS  Google Scholar 

  • Fukuda M. Roles of mucin-type O-glycans in cell adhesion. Biochim Biophys Acta. 2002;1573(3):394–405.

    PubMed  CrossRef  CAS  Google Scholar 

  • Fulcher JA, Chang MH, Wang S, Almazan T, Hashimi ST, Eriksson AU, et al. Galectin-1 co-clusters CD43/CD45 on dendritic cells and induces cell activation and migration through Syk and protein kinase C signaling. J Biol Chem. 2009;284(39):26860–70.

    PubMed  PubMed Central  CrossRef  CAS  Google Scholar 

  • Galindo-Albarrán AO, Ramírez-Pliego O, Labastida-Conde RG, Melchy-Pérez EI, Liquitaya-Montiel A, Esquivel-Guadarrama FR, et al. CD43 signals prepare human T cells to receive cytokine differentiation signals. J Cell Physiol. 2014;229(2):172–80.

    PubMed  CrossRef  CAS  Google Scholar 

  • Hartshorn KL, White MR. Influenza A virus up-regulates neutrophil adhesion molecules and adhesion to biological surfaces. J Leukoc Biol. 1999;65(5):614–22.

    PubMed  CrossRef  CAS  Google Scholar 

  • Hasegawa K, Tanaka S, Fujiki F, Morimoto S, Nakano K, Kinoshita H, et al. Glycosylation status of CD43 protein is associated with resistance of leukemia cells to CTL-mediated cytolysis. PLoS One. 2016;11(3):e0152326. doi:10.1371/journal.pone.0152326. eCollection 2016.

    CrossRef  PubMed  PubMed Central  CAS  Google Scholar 

  • Hernandez JD, Nguyen JT, He J, Wang W, Ardman B, Green JM, Fukuda M, Baum LG. Galectin-1 binds different CD43 glycoforms to cluster CD43 and regulate T cell death. J Immunol. 2006;177(8):5328–36.

    PubMed  CrossRef  CAS  Google Scholar 

  • Hickey TB, Ziltener HJ, Speert DP, Stokes RW. Mycobacterium tuberculosis employs Cpn60.2 as an adhesin that binds CD43 on the macrophage surface. Cell Microbiol. 2010;12(11):1634–47.

    PubMed  CrossRef  CAS  Google Scholar 

  • Humbria A, Diaz-Gonzalez F, Campanero MR, Arroyo AG, Laffon A, Gonzalez-Amaro R, et al. Expression of L-selectin, CD43, and CD44 in synovial fluid neutrophils from patients with inflammatory joint diseases. Evid soluble form L selectin synovial fluid Arthritis Rheum. 1994;37(3):342–8.

    CAS  Google Scholar 

  • Inui M, Hirota S, Hirano K, Fujii H, Sugahara-Tobinai A, Ishii T, et al. Human CD43+ B cells are closely related not only to memory B cells phenotypically but also to plasmablasts developmentally in healthy individuals. Int Immunol. 2015;27(7):345–355. doi:10.1093/intimm/dxv009. Epub 2015 Mar 5.

    CrossRef  PubMed  CAS  Google Scholar 

  • Johnson GG, Mikulowska A, Butcher EC, McEvoy LM, Michie SA. Anti-CD43 monoclonal antibody L11 blocks migration of T cells to inflamed pancreatic islets and prevents development of diabetes in nonobese diabetic mice. J Immunol. 1999;163(10):5678–85.

    PubMed  CAS  Google Scholar 

  • Kadaja L, Laos S, Maimets T. Overexpression of leukocyte marker CD43 causes activation of the tumor suppressor proteins p53 and ARF. Oncogene. 2004;23(14):2523–30.

    PubMed  CrossRef  CAS  Google Scholar 

  • Kadaja-Saarepuu L, Laos S, Jaager K, Viil J, Balikova A, Looke M, et al. CD43 promotes cell growth and helps to evade FAS-mediated apoptosis in non-hematopoietic cancer cells lacking the tumor suppressors p53 or ARF. Oncogene. 2008;27(12):1705–15 .Epub 2007 Sep 24

    PubMed  CrossRef  CAS  Google Scholar 

  • Khunkaewla P, Schiller HB, Paster W, Leksa V, Cermak L, Andera L, Horejsí V, Stockinger H. LFA-1-mediated leukocyte adhesion regulated by interaction of CD43 with LFA-1 and CD147. Mol Immunol. 2008;45(6):1703–11.

    PubMed  CrossRef  CAS  Google Scholar 

  • Lanteri M, Giordanengo V, Hiraoka N, Fuzibet JG, Auberger P, Fukuda M, et al. Altered T cell surface glycosylation in HIV-1 infection results in increased susceptibility to galectin-1-induced cell death. Glycobiology. 2003;13(12):909–18.

    PubMed  CrossRef  CAS  Google Scholar 

  • Laos S, Baeckström D, Hansson GC. Inhibition of NF-kB activation and chemokine expression by the leukocyte glycoprotein CD43 in colon cancer cells. Int J Oncol. 2006;28(3):695–704.

    PubMed  CAS  Google Scholar 

  • Leong AS, Cooper K, Leong FJ. Manual for diagnostic antibodies for immunohistology. 2nd ed. London: Greenwich Medical Media Ltd; 2003.

    Google Scholar 

  • Lopez S, Seveau S, Lesavre P, Robinson MK, Halbwachs-Mecarelli L. CD43 (sialophorin, leukosialin) shedding is an initial event during neutrophil migration, which could be closely related to the spreading of adherent cells. Cell Adhes Commun. 1998;5(2):151–60.

    PubMed  CrossRef  CAS  Google Scholar 

  • Manjunath N, Correa M, Ardman M, Ardman B. Negative regulation of T-cell adhesion and activation by CD43. Nature. 1995;377(6549):535–8.

    PubMed  CrossRef  CAS  Google Scholar 

  • Matsumoto M, Shigeta A, Miyasaka M, Hirata T. CD43 plays both antiadhesive and proadhesive roles in neutrophil rolling in a context-dependent manner. J Immunol. 2008;181(5):3628–35.

    PubMed  CrossRef  CAS  Google Scholar 

  • Miki Y, Itoh T, Hirano K, Eda S, Hayashi A, Yamanaka M, Beppu M. Clearance of oxidatively damaged cells by macrophages: recognition of glycoprotein clusters by macrophage-surface nucleolin as early apoptotic cells. Biol Pharm Bull. 2009;32(4):564–72.

    PubMed  CrossRef  CAS  Google Scholar 

  • Miki Y, Oguri E, Hirano K, Beppu M. Macrophage recognition of cells with elevated calcium is mediated by carbohydrate chains of CD43. Cell Struct Funct. 2013;38(1):43–54. Epub 2013 Feb 9.

    PubMed  CrossRef  CAS  Google Scholar 

  • Misawa Y, Nagaoka H, Kimoto H, Ishii Y, Kitamura K, Tsunetsugu-Yokota Y, Shibuya M, Takemori T. CD43 expression in a B cell lymphoma, WEHI 231, reduces susceptibility to G1 arrest and extends survival in culture upon serum depletion. Eur J Immunol. 1996;26(11):2573–81.

    PubMed  CrossRef  CAS  Google Scholar 

  • Montiel JL, Monsivais-Urenda A, Figueroa-Vega N, Moctezuma JF, Burgos-Vargas R, Gonzalez-Amaro R, Rosenstein Y. Anti-CD43 and anti-galectin-1 autoantibodies in patients with systemic lupus erythematosus. Scand J Rheumatol. 2010;39(1):50–7.

    PubMed  CrossRef  CAS  Google Scholar 

  • Nonomura C, Kikuchi J, Kiyokawa N, Ozaki H, Mitsunaga K, Ando H, et al. CD43, but not P-selectin glycoprotein ligand-1, functions as an E-selectin counter-receptor in human pre-B-cell leukemia NALL-1. Cancer Res. 2008;68(3):790–9.

    PubMed  CrossRef  CAS  Google Scholar 

  • Onami TM, Harrington LE, Williams MA, Galvan M, Larsen CP, Pearson TC, et al. Dynamic regulation of T cell immunity by CD43. J Immunol. 2002;168(12):6022–31.

    PubMed  CrossRef  CAS  Google Scholar 

  • Ostberg JR, Barth RK, Frelinger JG. The Roman god Janus: a paradigm for the function of CD43. Immunol Today. 1998;19(12):546–50.

    PubMed  CrossRef  CAS  Google Scholar 

  • Pallant A, Eskenazi A, Mattei MG, Fournier RE, Carlsson SR, Fukuda M, Frelinger JG. Characterization of cDNAs encoding human leukosialin and localization of the leukosialin gene to chromosome 16. Proc Natl Acad Sci USA. 1989;86(4):1328–32.

    PubMed  PubMed Central  CrossRef  CAS  Google Scholar 

  • Pedraza-Alva G, Rosenstein Y. CD43: one molecule, many tales to recount. Signal Transduction. 2007;7:372–85.

    CrossRef  CAS  Google Scholar 

  • Remold-O’Donnell E, Kenney DM, Parkman R, Cairns L, Savage B, Rosen FS. Characterization of a human lymphocyte surface sialoglycoprotein that is defective in Wiskott-Aldrich syndrome. J Exp Med. 1984;159(6):1705–23.

    PubMed  CrossRef  Google Scholar 

  • Ruhl S, Cisar JO, Sandberg AL. Identification of polymorphonuclear leukocyte and HL-60 cell receptors for adhesins of Streptococcus gordonii and Actinomyces naeslundii. Infect Immun. 2000;68(11):6346–54.

    PubMed  PubMed Central  CrossRef  CAS  Google Scholar 

  • Sakkas LI, Scanzello C, Johanson N, Burkholder J, Mitra A, Salgame P, et al. T cells and T-cell cytokine transcripts in the synovial membrane in patients with osteoarthritis. Clin Diagn Lab Immunol. 1998;5(4):430–7.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Seo W, Ziltener HJ. CD43 processing and nuclear translocation of CD43 cytoplasmic tail are required for cell homeostasis. Blood. 2009;114(17):3567–77.

    PubMed  CrossRef  CAS  Google Scholar 

  • Sperling AI, Green JM, Mosley RL, Smith PL, DiPaolo RJ, Klein JR, Bluestone JA, Thompson CB. CD43 is a murine T cell costimulatory receptor that functions independently of CD28. J Exp Med. 1995;182(1):139–46.

    PubMed  CrossRef  CAS  Google Scholar 

  • Szabady RL, Lokuta MA, Walters KB, Huttenlocher A, Welch RA. Modulation of neutrophil function by a secreted mucinase of Escherichia coli O157:H7. PLoS Pathog. 2009;5(2):e1000320.

    PubMed  PubMed Central  CrossRef  Google Scholar 

  • Tuccillo FM, de Laurentiis A, Camillo Palmieri C, Fiume G, Bonelli P, Borrelli A, et al. Aberrant glycosylation as biomarker for cancer: Focus on CD43. BioMed Res Int. 2014;2014:742831. doi:10.1155/2014/742831. Epub 2014 Feb 13.

    CrossRef  PubMed  PubMed Central  CAS  Google Scholar 

  • Velázquez F, Grodecki-Pena A, Knapp A, Salvador AM, Nevers T, Croce KJ, et al. CD43 functions as an E-selectin ligand for Th17 cells in vitro and is required for rolling on the vascular endothelium and Th17 cell recruitment during inflammation in vivo. J Immunol. 2016;196(3):1305–16. doi:10.4049/jimmunol.1501171. Epub 2015 Dec 23.

    CrossRef  PubMed  CAS  Google Scholar 

  • Zemelman BV, Chu SH, Walker WA. Host response to Escherichia coli heat-labile enterotoxin via two microvillus membrane receptors in the rat intestine. Infect Immun. 1989;57(10):2947–52.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Zhou H, Yan H, Cannon JL, Springer LE, Green JM, Pham CTN. CD43-mediated IFN-g production by CD8+ T cells promotes abdominal aortic aneurysm in mice. J Immunol. 2013;190(10):5078–85. doi:10.4049/jimmunol.1203228. Epub 2013 Apr 12.

    CrossRef  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Instituto de Biotecnología, Universidad Nacional Autónoma de México, Apartado Postal 510-3, Cuernavaca, Morelos, 62270, Mexico

    Alvaro Torres-Huerta, Estefania Aleman-Navarro, Maria Elena Bravo-Adame, Monserrat Alba Sandoval-Hernandez, Oscar Arturo Migueles-Lozano & Yvonne Rosenstein

Authors
  1. Alvaro Torres-Huerta
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Estefania Aleman-Navarro
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Maria Elena Bravo-Adame
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Monserrat Alba Sandoval-Hernandez
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Oscar Arturo Migueles-Lozano
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yvonne Rosenstein
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Alvaro Torres-Huerta .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

Rights and permissions

Reprints and Permissions

Copyright information

© 2018 Springer International Publishing AG

About this entry

Verify currency and authenticity via CrossMark

Cite this entry

Torres-Huerta, A., Aleman-Navarro, E., Bravo-Adame, M.E., Sandoval-Hernandez, M.A., Migueles-Lozano, O.A., Rosenstein, Y. (2018). CD43. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_523

Download citation