Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

DOCK2; Dedicator of Cytokinesis 2

  • Hiroshi NishiharaEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_518


Historical Background

DOCK2 was initially designated by Nishihara et al. in 1999 (Nishihara et al. 1999) as a hematopoietic cell-specific homologue of the CDM (ced-5 of Caenorhabditis elegans, DOCK180 of humans, and myoblast city of Drosophila melanogaster) family proteins. The name “DOCK” was originally designated as “Downstream of CRK” for DOCK180, an archetype of CDM family proteins in 1996 (Hasegawa et al. 1996).

Molecular Mechanism of DOCK2 as a Rac-Specific GEF (Guanine Nucleotide Exchange Factor)

In mammals, 11 DOCK180-related proteins have been identified, and the family members can be subcategorized into four groups denoted DOCK-A, -B, -C, and -D, and DOCK2 belongs to DOCK-A as well as DOCK180 (Fig. 1a) (Cote and Vuori 2007). The structural analysis revealed that DOCK2 consists of an SH3 domain in the N-terminus and DHR (DOCK homology region) -1/2 in the middle to C-terminus (Fig. 1b) (Cote and Vuori 2002). DHR-2 is highly conserved throughout...
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Graduate School of Medicine, Laboratory of Translational PathologyHokkaido UniversitySapporoJapan