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Encyclopedia of Signaling Molecules pp 312–319Cite as

Androgen Receptor (AR)

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Synonyms

NR3C4 (nuclear receptor subfamily 3, group C, member 4); Testosterone/dihydrotestosterone receptor

Historical Background

Androgen receptor (AR) mediates the effects of androgens that are responsible for diverse biological functions, such as development and maintenance of the male reproductive system, as well as involvement in disease states, such as prostate cancer (PCa) (for a review, see Brinkmann (2011)). AR is a ligand-activated transcription factor (TF) that belongs to the steroid hormone receptor (SHR) family within the nuclear receptor (NR) superfamily of TFs (for a review, see Huang et al. (2010)). In addition to AR, the SHR family contains the glucocorticoid receptor (GR), mineralocorticoid receptor (MR), progesterone receptor (PR), and the estrogen receptor (ER). SHRs are structurally and functionally related and mediate the action of steroid hormones that affect nearly all aspects of development and homeostasis; they are also implicated in a number of pathological...

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Androgen Receptor (AR), Fig. 1
Androgen Receptor (AR), Fig. 2
Androgen Receptor (AR), Fig. 3
Androgen Receptor (AR), Fig. 4

References

  • Attard G, Parker C, Eeles RA, Schroder F, Tomlins SA, Tannock I, et al. Prostate cancer. Lancet. 2016;387:70–82. doi:10.1016/S0140-6736(14)61947-4.

    CrossRef  PubMed  Google Scholar 

  • Baulieu EE, Jung I. A prostatic cytosol receptor. Biochem Biophys Res Commun. 1970;38:599–606.

    PubMed  CrossRef  CAS  Google Scholar 

  • Brinkmann AO. Molecular mechanisms of androgen action – a historical perspective. Methods Mol Biol. 2011;776:3–24. doi:10.1007/978-1-61779-243-4_1.

    CrossRef  PubMed  CAS  Google Scholar 

  • Caffo O, Maines F, Veccia A, Kinspergher S, Galligioni E. Splice variants of androgen receptor and prostate cancer. Oncol Rev. 2016;10:297. doi:10.4081/oncol.2016.297.

    CrossRef  PubMed  PubMed Central  CAS  Google Scholar 

  • Centenera MM, Harris JM, Tilley WD, Butler LM. The contribution of different androgen receptor domains to receptor dimerization and signaling. Mol Endocrinol. 2008;22:2373–82. doi:10.1210/me.2008-0017.

    CrossRef  PubMed  CAS  Google Scholar 

  • Chang CS, Kokontis J, Liao ST. Molecular cloning of human and rat complementary DNA encoding androgen receptors. Science. 1988;240:324–6.

    PubMed  CrossRef  CAS  Google Scholar 

  • Dehm S, Tindall DJ. Alternatively spliced androgen receptor variants. Endocr Relat Cancer. 2011. doi:10.1530/ERC-11-0141.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  • Fang S, Anderson KM, Liao S. Receptor proteins for androgens. On the role of specific proteins in selective retention of 17-beta-hydroxy-5-alpha-androstan-3-one by rat ventral prostate in vivo and in vitro. J Biol Chem. 1969;244:6584–95.

    PubMed  CAS  Google Scholar 

  • Foradori CD, Weiser MJ, Handa RJ. Non-genomic actions of androgens. Front Neuroendocrinol. 2008;29:169–81. doi:10.1016/j.yfrne.2007.10.005.

    CrossRef  PubMed  CAS  Google Scholar 

  • Gioeli D, Paschal BM. Post-translational modification of the androgen receptor. Mol Cell Endocrinol. 2011. doi:10.1016/j.mce.2011.07.004.

    CrossRef  PubMed  Google Scholar 

  • Huang P, Chandra V, Rastinejad F. Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics. Annu Rev Physiol. 2010;72:247–72. doi:10.1146/annurev-physiol-021909-135917.

    CrossRef  PubMed  PubMed Central  CAS  Google Scholar 

  • Klokk TI, Kurys P, Elbi C, Nagaich AK, Hendarwanto A, Slagsvold T, et al. Ligand-specific dynamics of the androgen receptor at its response element in living cells. Mol Cell Biol. 2007;27:1823–43. doi:10.1128/MCB.01297-06.

    CrossRef  PubMed  CAS  Google Scholar 

  • Koryakina Y, Ta HQ, Gioeli D. Androgen receptor phosphorylation: biological context and functional consequences. Endocr Relat Cancer. 2014;21:T131–45. doi:10.1530/ERC-13-0472.

    CrossRef  PubMed  PubMed Central  CAS  Google Scholar 

  • Kumar R, Atamna H, Zakharov MN, Bhasin S, Khan SH, Jasuja R. Role of the androgen receptor CAG repeat polymorphism in prostate cancer, and spinal and bulbar muscular atrophy. Life Sci. 2011;88:565–71. doi:10.1016/j.lfs.2011.01.021.

    CrossRef  PubMed  CAS  Google Scholar 

  • Lamb DJ, Weigel NL, Marcelli M. Androgen receptors and their biology. Vitam Horm. 2001;62:199–230.

    PubMed  CrossRef  CAS  Google Scholar 

  • Liao RS, Ma S, Miao L, Li R, Yin Y, Raj GV. Androgen receptor-mediated non-genomic regulation of prostate cancer cell proliferation. Transl Androl Urol. 2013;2:187–96. doi:10.3978/j.issn.2223-4683.2013.09.07.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  • Lubahn DB, Joseph DR, Sullivan PM, Willard HF, French FS, Wilson EM. Cloning of human androgen receptor complementary DNA and localization to the X chromosome. Science. 1988;240:327–30.

    PubMed  CrossRef  CAS  Google Scholar 

  • Mainwaring WI. A soluble androgen receptor in the cytoplasm of rat prostate. J Endocrinol. 1969;45:531–41.

    PubMed  CrossRef  CAS  Google Scholar 

  • Matsumoto T, Sakari M, Okada M, Yokoyama A, Takahashi S, Kouzmenko A, et al. The androgen receptor in health and disease. Annu Rev Physiol. 2013;75:201–24. doi:10.1146/annurev-physiol-030212-183656.

    CrossRef  PubMed  CAS  Google Scholar 

  • Mills IG. Maintaining and reprogramming genomic androgen receptor activity in prostate cancer. Nat Rev Cancer. 2014;14:187–98. doi:10.1038/nrc3678.

    CrossRef  PubMed  CAS  Google Scholar 

  • Mongan NP, Tadokoro-Cuccaro R, Bunch T, Hughes IA. Androgen insensitivity syndrome. Best Pract Res Clin Endocrinol Metab. 2015;29:569–80. doi:10.1016/j.beem.2015.04.005.

    CrossRef  PubMed  CAS  Google Scholar 

  • Shukla GC, Plaga AR, Shankar E, Gupta S. Androgen receptor-related diseases: what do we know? Andrology. 2016;4:366–81. doi:10.1111/andr.12167.

    CrossRef  PubMed  CAS  Google Scholar 

  • Tilley WD, Marcelli M, Wilson JD, McPhaul MJ. Characterization and expression of a cDNA encoding the human androgen receptor. Proc Natl Acad Sci U S A. 1989;86:327–31.

    PubMed  PubMed Central  CrossRef  CAS  Google Scholar 

  • Trapman J, Klaassen P, Kuiper GG, van der Korput JA, Faber PW, van Rooij HC, et al. Cloning, structure and expression of a cDNA encoding the human androgen receptor. Biochem Biophys Res Commun. 1988;153:241–8.

    PubMed  CrossRef  CAS  Google Scholar 

  • van de Wijngaart DJ, Dubbink HJ, van Royen ME, Trapman J, Jenster G. Androgen receptor coregulators: recruitment via the coactivator binding groove. Mol Cell Endocrinol. 2012;352:57–69. doi:10.1016/j.mce.2011.08.007.

    CrossRef  PubMed  CAS  Google Scholar 

  • Wang D, Tindall DJ. Androgen action during prostate carcinogenesis. Methods Mol Biol. 2011;776:25–44. doi:10.1007/978-1-61779-243-4_2.

    CrossRef  PubMed  CAS  Google Scholar 

  • Wilson EM. Analysis of interdomain interactions of the androgen receptor. Methods Mol Biol. 2011;776:113–29. doi:10.1007/978-1-61779-243-4_8.

    CrossRef  PubMed  PubMed Central  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Biosciences, University of Oslo, Postboks 1066 Blindern, 0316, Oslo, Norway

    Hatice Zeynep Nenseth, Martina Tesikova & Fahri Saatcioglu

  2. Institute for Cancer Genetics and Informatics, Oslo University Hospital, Oslo, Norway

    Fahri Saatcioglu

Authors
  1. Hatice Zeynep Nenseth
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  2. Martina Tesikova
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  3. Fahri Saatcioglu
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Corresponding author

Correspondence to Fahri Saatcioglu .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Nenseth, H.Z., Tesikova, M., Saatcioglu, F. (2018). Androgen Receptor (AR). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_514

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