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Encyclopedia of Signaling Molecules pp 3208–3214Cite as

MOZ and MORF Lysine Acetyltransferases

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Synonyms

MORF (MOZ-related factor): KAT6B; Lysine (K) acetyltransferase 6B; MYST4; Querkopf

MOZ (monocytic leukemia zinc-finger protein): KAT6A; Lysine (K) acetyltransferase 6A; MYST3

Historical Background

MOZ is a founding member of the MYST (MOZ, YBF2, SAS2, and TIP60) family of lysine acetyltransferases (Borrow et al. 1996; Reifsnyder et al. 1996; reviewed in Yang and Ullah 2007). It was identified in 1996 through positional cloning of the reciprocal chromosomal t(8;16)(p11;p13) translocation with CREB-binding protein (CBP) associated with a subset of acute myeloid leukemia (AML) (Borrow et al. 1996). A few years later, the acetyltransferase activity was demonstrated and mapped to the MYST domain (Champagne et al. 2001; Kitabayashi et al. 2001a). Human MORF was identified in BLAST search against expressed sequence tag databases for additional MYST proteins (Champagne et al. 1999). Mouse Morf was also identified as Querkopf, a mutant allele causing craniofacial abnormalities (Thomas...

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Acknowledgments

This research was supported by operating grants from Canadian Institutes of Health Research (CIHR) and Canadian Cancer Society (to X. J. Y.).

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Authors and Affiliations

  1. The Rosalind and Morris Goodman Cancer Research Center and Department of Biochemistry, McGill University, Montréal, QC, H3A 1A3, Canada

    Jiang-Ping Zhang, Xiaoyu Du, Kezhi Yan & Xiang-Jiao Yang

  2. Department of Medicine, McGill University Health Center, Montréal, QC, H3A 1A3, Canada

    Jiang-Ping Zhang, Xiaoyu Du, Kezhi Yan & Xiang-Jiao Yang

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  1. Jiang-Ping Zhang
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  2. Xiaoyu Du
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  3. Kezhi Yan
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  4. Xiang-Jiao Yang
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Correspondence to Xiang-Jiao Yang .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Zhang, JP., Du, X., Yan, K., Yang, XJ. (2018). MOZ and MORF Lysine Acetyltransferases. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_510

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