Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

MOZ and MORF Lysine Acetyltransferases

  • Jiang-Ping Zhang
  • Xiaoyu Du
  • Kezhi Yan
  • Xiang-Jiao YangEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_510


MORF (MOZ-related factor):  KAT6B;  Lysine (K) acetyltransferase 6B;  MYST4;  Querkopf

MOZ (monocytic leukemia zinc-finger protein):  KAT6A;  Lysine (K) acetyltransferase 6A;  MYST3

Historical Background

MOZ is a founding member of the MYST ( MOZ, YBF2, SAS2, and TIP60) family of lysine acetyltransferases (Borrow et al. 1996; Reifsnyder et al. 1996; reviewed in Yang and Ullah 2007). It was identified in 1996 through positional cloning of the reciprocal chromosomal t(8;16)(p11;p13) translocation with CREB-binding protein (CBP) associated with a subset of acute myeloid leukemia (AML) (Borrow et al. 1996). A few years later, the acetyltransferase activity was demonstrated and mapped to the MYST domain (Champagne et al. 2001; Kitabayashi et al. 2001a). Human MORF was identified in BLAST search against expressed sequence tag databases for additional MYST proteins (Champagne et al. 1999). Mouse Morf was also identified as Querkopf, a mutant allele causing craniofacial abnormalities...
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This research was supported by operating grants from Canadian Institutes of Health Research (CIHR) and Canadian Cancer Society (to X. J. Y.).


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Jiang-Ping Zhang
    • 1
    • 2
  • Xiaoyu Du
    • 1
    • 2
  • Kezhi Yan
    • 1
    • 2
  • Xiang-Jiao Yang
    • 1
    • 2
    Email author
  1. 1.The Rosalind and Morris Goodman Cancer Research Center and Department of BiochemistryMcGill UniversityMontréalCanada
  2. 2.Department of MedicineMcGill University Health CenterMontréalCanada