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CEACAMs

  • Reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 200 Accesses

Synonyms

Bgp; C-CAM; CD66

Alternative Names

CEACAM1: Bb-1; Bgp; Bgp1; Bgpa (human); Bgpd (mouse); BGPI; Biliary glycoprotein 1; C-CAM; C-CAM105; NCA-160; nonspecific cross-reacting antigen 160; CD66; CD66a; Cea-1; Cea-7; CEA-related cell adhesion molecule 1; Cea1; Cea7; Carcinoembryonic antigen-related cell adhesion molecule 1; CEACAM1; Ceacam1; mCEA1; MHVR; mmCGM1; mmCGM1a; mmCGM2, CEACAM3: CD66d; CGM1; MGC119875; W264; W282, CEACAM4: CGM7, CEACAM5: CEA; CD66e, CEACAM6: CD66c; NCA; NCA-90; NCA-50/90; CEAL, CEACAM7: CGM2, CEACAM8: CD66b; CD67; CGM6; NCA-95, CEACAM9; CEACAM10; CEACAM11; CEACAM12, CEACAM13, CEACAM14, CEACAM15, CEACAM16, CEACAM17, CEACAM18, CEACAM19, CEACAM20, and CEACAM21: no synonyms

Historical Background

CEA-related cell adhesion molecules (CEACAMs) are members of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEAgene family, the CEA-related cell adhesion molecules and the pregnancy-specific...

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References

  • Beauchemin N, Draber P, Dveksler G, Gold P, Gray-Owen S, Grunert F, Hammarström S, Holmes KV, Karlsson A, Kuroki M, Lin SH, Lucka L, Najjar SM, Neumaier M, Öbrink B, Shively JE, Skubitz KM, Stanners CP, Thomas P, Thompson JA, Virji M, von Kleist S, Wagener C, Watt S, Zimmermann W. Redefined nomenclature for members of the carcinoembryonic antigen family. Exp Cell Res. 1999;252(2):243–9.

    Article  PubMed  CAS  Google Scholar 

  • Beauchemin N, Arabzadeh A. Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis. Cancer Metastasis Rev. 2013;32(3–4):643–71. https://doi.org/10.1007/s10555-013-9444-6.

    Article  PubMed  CAS  Google Scholar 

  • Duxbury MS, Ito H, Ashley SW, Whang EE. CEACAM6 cross-linking induces caveolin-1-dependent, Src-mediated focal adhesion kinase phosphorylation in BxPC3 pancreatic adenocarcinoma cells. J Biol Chem. 2004;279(22):23176–82.

    Article  PubMed  CAS  Google Scholar 

  • Gray-Owen SD, Blumberg RS. CEACAM1: contact-dependent control of immunity. Nat Rev Immunol. 2006;6(6):433–46.

    Article  PubMed  CAS  Google Scholar 

  • Greicius G, Severinson E, Beauchemin N, Öbrink B, Singer BB. CEACAM1 is a potent regulator of B cell receptor complex-induced activation. J Leukoc Biol. 2003;74(1):126–34.

    Article  PubMed  CAS  Google Scholar 

  • Hammarström S. The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. Semin Cancer Biol. 1999;9(2):67–81.

    Article  PubMed  Google Scholar 

  • Horst AK, Wagener C. CEA-related CAMs. In Handbook of experimental pharmacology. New York: Springer; 2004. p. 283–341.

    Google Scholar 

  • Javaheri A, Kruse T, Moonens K, Mejías-Luque R, Debraekeleer A, Asche CI, Tegtmeyer N, Kalali B, Bach NC, Sieber SA, Hill DJ, Königer V, Hauck CR, Moskalenko R, Haas R, Busch DH, Klaile E, Slevogt H, Schmidt A, Backert S, Remaut H, Singer BB, Gerhard M. Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs. Nat Microbiol. 2016 Oct 17;2:16189. doi: 10.1038/nmicrobiol.2016.189.PMID: 27748768

    Google Scholar 

  • Kammerer R, Zimmermann W. Coevolution of activating and inhibitory receptors within mammalian carcinoembryonic antigen families. BMC Biol. 2010;8:12.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Khairnar V, Duhan V, Maney SK, Honke N, Shaabani N, Pandyra AA, Seifert M, Pozdeev V, Xu HC, Sharma P, Baldin F, Marquardsen F, Merches K, Lang E, Kirschning C, Westendorf AM, Häussinger D, Lang F, Dittmer U, Küppers R, Recher M, Hardt C, Scheffrahn I, Beauchemin N, Göthert JR, Singer BB, Lang PA, Lang KS. CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production. Nat Commun. 2015;6:6217. https://doi.org/10.1038/ncomms7217.

    Article  PubMed  CAS  Google Scholar 

  • Kilic N, Oliveira-Ferrer L, Neshat-Vahid S, Irmak S, Obst-Pernberg K, Wurmbach JH, Loges S, Kilic E, Weil J, Lauke H, Tilki D, Singer BB, Ergün S. Lymphatic reprogramming of microvascular endothelial cells by CEA-related cell adhesion molecule-1 via interaction with VEGFR-3 and Prox1. Blood. 2007;110(13):4223–33.

    Article  PubMed  CAS  Google Scholar 

  • Klaile E, Müller MM, Kannicht C, Otto W, Singer BB, Reutter W, Öbrink B, Lucka L. The cell adhesion receptor carcinoembryonic antigen-related cell adhesion molecule 1 regulates nucleocytoplasmic trafficking of DNA polymerase delta-interacting protein 38. J Biol Chem. 2007;282(36):26629–40.

    Article  PubMed  CAS  Google Scholar 

  • Klaile E, Vorontsova O, Sigmundsson K, Müller MM, Singer BB, Ofverstedt LG, Svensson S, Skoglund U, Obrink B. The CEACAM1 N-terminal Ig domain mediates cis- and trans-binding and is essential for allosteric rearrangements of CEACAM1 microclusters. J Cell Biol. 2009;187(4):553–67. https://doi.org/10.1083/jcb.200904149.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kuespert K, Pils S, Hauck CR. CEACAMs: their role in physiology and pathophysiology. Curr Opin Cell Biol. 2006;18(5):565–71.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Lobo EO, Zhang Z, Shively JE. Pivotal advance: CEACAM1 is a negative coreceptor for the B cell receptor and promotes CD19-mediated adhesion of B cells in a PI3K-dependent manner. J Leukoc Biol. 2009;86(2):205–18.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Müller MM, Klaile E, Vorontsova O, Singer BB, Obrink B. Homophilic adhesion and CEACAM1-S regulate dimerization of CEACAM1-L and recruitment of SHP-2 and c-Src. J Cell Biol. 2009;187(4):569–81.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Muturi HT, Dreesen JD, Nilewski E, Jastrow H, Giebel B, Ergun S, Singer BB. Tumor and endothelial cell-derived microvesicles carry distinct CEACAMs and influence T-cell behavior. PLoS One. 2013;8(9):e74654. https://doi.org/10.1371/journal.pone.0074654. eCollection 2013

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Nouvion A-L, Oubaha M, LeBlanc S, Davis EC, Jastrow H, Kammerer R, Breton V, Turbide C, Ergun S, Gratton J-P, Beauchemin N. CEACAM1: a key regulator of vascular permeability. J Cell Sci. 2010;123:4221–30.

    Article  PubMed  CAS  Google Scholar 

  • Öbrink B. CEA adhesion molecules: multifunctional proteins with signal-regulatory properties. Curr Opin Cell Biol. 1997;9(5):616–26.

    Article  PubMed  PubMed Central  Google Scholar 

  • Öbrink B. On the role of CEACAM1 in cancer. Lung Cancer. 2008;60(3):309–12.

    Article  PubMed  Google Scholar 

  • Pan H, Shively JE. Carcinoembryonic antigen-related cell adhesion molecule-1 regulates granulopoiesis by inhibition of granulocyte colony-stimulating factor receptor. Immunity. 2010;33(4):620–31.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Sadarangani M, Pollard AJ, Gray-Owen SD. Opa proteins & CEACAMs: pathways of immune engagement for pathogenic Neisseria. FEMS Microbiol Rev. 2010;35(3):498–514. https://doi.org/10.1111/j.1574-6976.2010.00260.x.

    Article  CAS  Google Scholar 

  • Singer BB, Lucka L. CEACAM1. UCSD-nature molecule pages. 2005. https://doi.org/10.1038/mp.a003597.01.

  • Singer BB, Scheffrahn I, Heymann R, Sigmundsson K, Kammerer R, Öbrink B. Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes. J Immunol. 2002;168(10):5139–46.

    Article  PubMed  CAS  Google Scholar 

  • Singer BB, Scheffrahn I, Kammerer R, Suttorp N, Ergun S, Slevogt H. Deregulation of the CEACAM expression pattern causes undifferentiated cell growth in human lung adenocarcinoma cells. PLoS One. 2010;5(1):e8747.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Slevogt H, Zabel S, Opitz B, Hocke A, Eitel J, N’guessan PD, Lucka L, Riesbeck K, Zimmermann W, Zweigner J, Temmesfeld-Wollbrueck B, Suttorp N, Singer BB. CEACAM1 inhibits Toll-like receptor 2-triggered antibacterial responses of human pulmonary epithelial cells. Nat Immunol. 2008;9(11):1270–8.

    Article  PubMed  CAS  Google Scholar 

  • Tchoupa AK, Schuhmacher T, Hauck CR. Signaling by epithelial members of the CEACAM family – mucosal docking sites for pathogenic bacteria. Cell Commun Signal. 2014;12:27. https://doi.org/10.1186/1478-811X-12-27.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Anatomy, University Hospital Essen, University of Duisburg-Essen, Virchowstrasse 171, 45122, Essen, NRW, Germany

    Bernhard B. Singer

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  1. Bernhard B. Singer
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Correspondence to Bernhard B. Singer .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Singer, B.B. (2018). CEACAMs. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_508

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