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Zinc Transport in the Pancreatic β-Cell: Roles of ZnT (SLC30A) and ZiP (SLC39A) Family Members

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References

  • Bellomo EA, Meur G, et al. Glucose regulates free cytosolic Zn2+ concentration, Slc39 (ZiP), and metallothionein gene expression in primary pancreatic islet {beta}-cells. J Biol Chem. 2011;286(29):25778–89.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Chimienti F, Devergnas S, et al. In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion. J Cell Sci. 2006;119(Pt 20):4199–206.

    Article  CAS  PubMed  Google Scholar 

  • Gyulkhandanyan AV, Lu H, et al. Investigation of transport mechanisms and regulation of intracellular Zn2+ in pancreatic alpha-cells. J Biol Chem. 2008;283(15):10184–97.

    Article  CAS  PubMed  Google Scholar 

  • Huang X, Cuajungco MP, et al. Alzheimer’s disease, beta-amyloid protein and zinc. J Nutr. 2000;130(5S Suppl):1488S–92.

    Article  CAS  PubMed  Google Scholar 

  • Hutton JC, Bailyes EM, et al. Biosynthesis and storage of insulin. Biochem Soc Trans. 1990;18(1):122–4.

    Article  CAS  PubMed  Google Scholar 

  • Kambe T, Narita H, et al. Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells. J Biol Chem. 2002;277(21):19049–55.

    Article  CAS  PubMed  Google Scholar 

  • Kanoni S, Nettleton JA, et al. Total zinc intake may modify the Glucose-Raising effect of a zinc transporter (SLC30A8) variant: a 14-cohort meta-analysis. Diabetes. 2011;60(9):2407–16. Epub 2011 Aug 1.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Li M, Zhang Y, et al. Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression. Proc Natl Acad Sci U S A. 2007;104(47):18636–41.

    Article  PubMed  PubMed Central  Google Scholar 

  • Lichten LA, Cousins RJ. Mammalian zinc transporters: nutritional and physiologic regulation. Annu Rev Nutr. 2009;29:153–76.

    Article  PubMed  Google Scholar 

  • Nicolson TJ, Bellomo EA, et al. Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants. Diabetes. 2009;58(9):2070–83.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Palmiter RD, Cole TB, et al. ZnT-3, a putative transporter of zinc into synaptic vesicles. Proc Natl Acad Sci U S A. 1996;93(25):14934–9.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Rutter GA. Think zinc: new roles for zinc in the control of insulin secretion. Islets. 2010;2(1):49–50.

    Article  PubMed  Google Scholar 

  • Scott DA, Fisher AM. The insulin and the zinc content of normal and diabetic pancreas. J Clin Invest. 1938;17(6):725–8.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Seve M, Chimienti F, et al. In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters’ tissue expression. BMC Genomics. 2004;5(1):32.

    Article  PubMed  PubMed Central  Google Scholar 

  • Simons TJ. Calcium-dependent zinc efflux in human red blood cells. J Membr Biol. 1991;123(1):73–82.

    Article  CAS  PubMed  Google Scholar 

  • Sladek R, Rocheleau G, et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature. 2007;445(7130):881–5.

    Article  CAS  PubMed  Google Scholar 

  • Smidt K, Jessen N, et al. SLC30A3 responds to glucose- and zinc variations in beta-cells and is critical for insulin production and in vivo glucose-metabolism during beta-cell stress. PLoS One. 2009;4(5):e5684.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Taylor KM, Nicholson RI. The LZT proteins; the LIV-1 subfamily of zinc transporters. Biochim Biophys Acta. 2003;1611(1–2):16–30.

    Article  CAS  PubMed  Google Scholar 

  • Taylor KM, Morgan HE, et al. The emerging role of the LIV-1 subfamily of zinc transporters in breast cancer. Mol Med. 2007;13(7–8):396–406.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Vinkenborg JL, Nicolson TJ, et al. Genetically encoded FRET sensors to monitor intracellular Zn2+ homeostasis. Nat Methods. 2009;6(10):737–40.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang B, Schneider SN, et al. Enhanced cadmium-induced testicular necrosis and renal proximal tubule damage caused by gene-dose increase in a Slc39a8-transgenic mouse line. Am J Physiol Cell Physiol. 2007;292(4):C1523–35.

    Article  CAS  PubMed  Google Scholar 

  • Wijesekara N, Chimienti F, et al. Zinc, a regulator of islet function and glucose homeostasis. Diabetes Obes Metab. 2009;11(Suppl 4):202–14.

    Article  CAS  PubMed  Google Scholar 

  • Wijesekara N, Dai FF, et al. Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion. Diabetologia. 2010;53(8):1656–68.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Williams NR, Rajput-Williams J, et al. Plasma, granulocyte and mononuclear cell copper and zinc in patients with diabetes mellitus. Analyst. 1995;120(3):887–90.

    Article  CAS  PubMed  Google Scholar 

  • Zhang Y, Bharadwaj U, et al. ZIP4 regulates pancreatic cancer cell growth by activating IL-6/STAT3 pathway through zinc finger transcription factor CREB. Clin Cancer Res. 2010;16(5):1423–30.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Correspondence to Elisa A. Bellomo .

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Bellomo, E.A., Rutter, G.A. (2018). Zinc Transport in the Pancreatic β-Cell: Roles of ZnT (SLC30A) and ZiP (SLC39A) Family Members. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_499

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