Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Simon N. S. LouisEmail author
  • Naghmeh Varghayee
  • Laurie T. C. Chow
  • William J. Louis
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_497


Historical Background

Following its initial identification in Japan in 1999 (Nagase et al. 1999), mitochondrial tumor suppressor 1 (MTUS1/ATIP) (2011), a putative tumor suppressor gene, has been independently identified by research groups from Japan (Kinjo et al. 2000), Germany (Seibold et al. 2003; Wruck et al. 2005), and France (Nouet et al. 2004). As a result, MTUS1/ATIP has been designated a variety of different names; therefore, the nomenclature used to describe MTUS1/ATIP in publications can be confusing.

MTUS1/ATIP was first identified in 1999 following the sequencing of 100 cDNA clones of unknown human genes from two sets of size-fractionated human adult and fetal brain cDNA libraries (Nagase et al. 1999). At this time, it...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Simon N. S. Louis
    • 1
    Email author
  • Naghmeh Varghayee
    • 1
  • Laurie T. C. Chow
    • 1
  • William J. Louis
    • 1
  1. 1.Clinical Pharmacology Unit, Department of Medicine Austin Health/Northern HealthUniversity of MelbourneHeidelbergAustralia