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Encyclopedia of Signaling Molecules pp 3924–3929Cite as

PHLDA1 (Pleckstrin Homology-Like Domain, Family A, Member 1)

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Synonyms

DT1P1B11; MGC131738; PHRIP; TDAG51

Historical Background

PHLDA1 (pleckstrin homology-like domain, family A, member 1) gene encodes for a member of an evolutionarily conserved pleckstrin homology-related domain protein family and was first identified as a potential transcription factor required for Fas expression and activation-induced apoptosis in mouse T cell hybridomes (Park et al. 1996). Further PHLDA1 homologs were identified and isolated in rat (Gomes et al. 1999) and human (Kuske and Johnson 2000) and sequencing comparison showed that mouse, human, and rat PHLDA1 cDNAs exhibit high level of identity. The genes encoding for the members of the pleckstrin homology-related domain protein family are located in different chromosomes, PHLDA1 (also named PHRIP/TDAG51/DT1P1B11/MGC131738; 12q21.2), PHLDA2 (also named IPL/BRWR1C/HLDA2/TSSC3; 11p15.4), and PHLDA3 (also named TIH1; 1q32.1), but have a similar simple gene structure with two exons (one coding exon) and a small intron...

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Authors and Affiliations

  1. Disciplina de Oncologia, Departamento de Radiologia da Faculdade de Medicina da Universidade de São Paulo, Centro de Investigação Translacional em Oncologia, Laboratório de Genética Molecular, Instituto do Cancer de São Paulo, Universidade de São Paulo, Av. Dr. Arnaldo 251, 8o andar, 01246-000, São Paulo, Brazil

    Maria Aparecida Nagai

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  1. Maria Aparecida Nagai
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Correspondence to Maria Aparecida Nagai .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Nagai, M.A. (2018). PHLDA1 (Pleckstrin Homology-Like Domain, Family A, Member 1). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_483

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