Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

PHLDA1 (Pleckstrin Homology-Like Domain, Family A, Member 1)

  • Maria Aparecida NagaiEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_483


Historical Background

PHLDA1 (pleckstrin homology-like domain, family A, member 1) gene encodes for a member of an evolutionarily conserved pleckstrin homology-related domain protein family and was first identified as a potential transcription factor required for Fas expression and activation-induced apoptosis in mouse T cell hybridomes (Park et al. 1996). Further PHLDA1 homologs were identified and isolated in rat (Gomes et al. 1999) and human (Kuske and Johnson 2000) and sequencing comparison showed that mouse, human, and rat PHLDA1 cDNAs exhibit high level of identity. The genes encoding for the members of the pleckstrin homology-related domain protein family are located in different chromosomes, PHLDA1 (also named PHRIP/TDAG51/DT1P1B11/MGC131738; 12q21.2), PHLDA2 (also named IPL/BRWR1C/HLDA2/TSSC3; 11p15.4), and PHLDA3 (also named TIH1; 1q32.1), but have a similar simple gene structure with two exons (one coding exon) and a small...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Disciplina de Oncologia, Departamento de Radiologia da Faculdade de Medicina da Universidade de São Paulo, Centro de Investigação Translacional em Oncologia, Laboratório de Genética Molecular, Instituto do Cancer de São PauloUniversidade de São PauloSão PauloBrazil