PHLDA1 (Pleckstrin Homology-Like Domain, Family A, Member 1)
PHLDA1 (pleckstrin homology-like domain, family A, member 1) gene encodes for a member of an evolutionarily conserved pleckstrin homology-related domain protein family and was first identified as a potential transcription factor required for Fas expression and activation-induced apoptosis in mouse T cell hybridomes (Park et al. 1996). Further PHLDA1 homologs were identified and isolated in rat (Gomes et al. 1999) and human (Kuske and Johnson 2000) and sequencing comparison showed that mouse, human, and rat PHLDA1 cDNAs exhibit high level of identity. The genes encoding for the members of the pleckstrin homology-related domain protein family are located in different chromosomes, PHLDA1 (also named PHRIP/TDAG51/DT1P1B11/MGC131738; 12q21.2), PHLDA2 (also named IPL/BRWR1C/HLDA2/TSSC3; 11p15.4), and PHLDA3 (also named TIH1; 1q32.1), but have a similar simple gene structure with two exons (one coding exon) and a small...
- Hossain GS, van Thienen JV, Werstuck GH, Zhou J, Sood SK, Dickhout JG, de Koning AB, Tang D, Wu D, Falk E, Poddar R, Jacobsen DW, Zhang K, Kaufman RJ, Austin RC. TDAG51 is induced by homocysteine, promotes detachment-mediated programmed cell death, and contributes to the cevelopment of atherosclerosis in hyperhomocysteinemia. J Biol Chem. 2003;278(32):30317–27.CrossRefPubMedGoogle Scholar
- Ren L, Mendoza A, Zhu J, Briggs JW, Halsey C, Hong ES, Burkett SS, Morrow J, Lizardo MM, Osborne T, Li SQ, Luu HH, Meltzer P, Khanna C. Characterization of the metastatic phenotype of a panel of established osteosarcoma cells. Oncotarget. 2015;6(30):29469–81.PubMedPubMedCentralCrossRefGoogle Scholar
- Sakthianandeswaren A, Christie M, D'Andreti C, Tsui C, Jorissen RN, Li S, Fleming NI, Gibbs P, Lipton L, Malaterre J, Ramsay RG, Phesse TJ, Ernst M, Jeffery RE, Poulsom R, Leedham SJ, Segditsas S, Tomlinson IP, Bernhard OK, Simpson RJ, Walker F, Faux MC, Church N, Catimel B, Flanagan DJ, Vincan E, Sieber OM. PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis. Cancer Res. 2011;71(10):3709–19.CrossRefPubMedGoogle Scholar
- Sellheyer K, Nelson P. Follicular stem cell marker PHLDA1 (TDAG51) is superior to cytokeratin-20 in differentiating between trichoepithelioma and basal cell carcinoma in small biopsy specimens. J Cutan Pathol. 2011;38(7):542–50. https://doi.org/10.1111/j.1600-0560.2011.01693.x.CrossRefPubMedGoogle Scholar