B lymphocytes express several surface molecules other than the B cell receptors (BCR) that function as markers of differentiation as well as molecules that can fine tune BCR signaling. Current research has identified a function for most antigens that were previously classified as markers of lymphocyte differentiation. CD72 is one such molecule that was originally discovered as a marker of B cell differentiation using conventional serological and classical genetic techniques. Subsequently generation of monoclonal antibodies helped its definition as a molecule that can affect B cell growth and differentiation on its own or in the context of BCR signaling. Initially Sato and Boyse described an activity in sera from C3H.I mice immunized with 1.29 ascites tumor cells that reacted only with a subset of spleen cells after it was absorbed to remove an unknown reactivity. Subsequently the cell type in the spleen...
- Eriksson EM, Milush JM, Ho EL, Batista MD, Holditch SJ, Keh CE, Norris PJ, Keating SM, Deeks SG, Hunt PW, Martin JN, Rosenberg MG, Hecht FM, Nixon DF. Expansion of CD8+ T cells lacking Sema4D/CD100 during HIV-1 infection identifies a subset of T cells with decreased functional capacity. Blood. 2012;119:745–55.PubMedPubMedCentralCrossRefGoogle Scholar
- Hitomi Y, Tsuchiya N, Kawasaki A, Kyogoku C, Ohashi J, Suzuki T, Fukazawa T, Bejrachandra S, Siriboonrit U, Chandanayingyong D, Suthipinittharm P, Tsao BP, Hashimoto H, Honda Z-I, Tokunaga K. CD72 polymorphisms associated with alternative splicing modify susceptibility to human systemic lupus erythematosus through epistatic interaction with FCGR2B. Hum Mol Genet. 2004 Dec 1;13(23):2907–17.Google Scholar
- Kumanogoh A, Shikina T, Watanabe C, Takegahara N, Suzuki K, Yamamoto M, Takamatsu H, Prasad DV, Mizui M, Toyofuku T, Tamura M, Watanabe D, Parnes JR, Kikutani H. Requirement for CD100-CD72 interactions in fine-tuning of B-cell antigen receptor signaling and homeostatic maintenance of the B-cell compartment. Int Immunol. 2005;17:1277–82.PubMedCrossRefGoogle Scholar
- Mimori K, Kiyokawa N, Taguchi T, Suzuki T, Sekino T, Nakajima H, Saito M, Katagiri YU, Isoyama K, Yamada K, Matsuo Y, Fujimoto J. Costimulatory signals distinctively affect CD20- and B-cell-antigen-receptor-mediated apoptosis in Burkitt’s lymphoma/leukemia cells. Leukemia. 2003;17:1164–74.PubMedCrossRefGoogle Scholar
- Vadasz Z, Goldeberg Y, Halasz K, Rosner I, Valesini G, Conti F, Perricone C, Sthoeger Z, Bezalel SR, Tzioufas AG, Levin NA, Shoenfeld Y, Toubi E. Increased soluble CD72 in systemic lupus erythematosus is in association with disease activity and lupus nephritis. Clin Immunol. 2016;164:114–8.PubMedCrossRefGoogle Scholar
- Wu H-J. The positive signaling role of CD72 in B lymphocyte activation and function (doctoral thesis). In: Microbiology, immunology and molecular genetics. University of Kentucky, Lexington; 2002.Google Scholar
- Wu HJ, Venkataraman C, Estus S, Dong C, Davis RJ, Flavell RA, Bondada S. Positive signaling through CD72 induces mitogen-activated protein kinase activation and synergizes with B cell receptor signals to induce X-linked immunodeficiency B cell proliferation. J Immunol. 2001;167:1263–73.PubMedCrossRefGoogle Scholar