Historical Background
p130Cas is a major substrate of the Src tyrosine kinase that functions in integrin signaling to promote cell motility, invasion, proliferation, and survival (reviewed by Defillipi et al. 2006; Tikhmyanova et al. 2010). p130Cas was first recognized in the late 1980s by immunoblot detection with an anti-phosphotyrosine antibody in cells transformed by retroviral oncogenes v-crk and v-src. The p130 designation indicates the apparent molecular mass of ∼130 kDa during SDS polyacrylamide gel electrophoresis (PAGE), and Cas is acronymic for “Crk-associated substrate.” Characterization of the direct interactions of p130Cas with the v-Crk and v-Src proteins was significant in the recognition of Src homology 2 (SH2) domains as phosphotyrosine-binding modules in signal transduction. p130Cas was independently identified as a...
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Donato, D.M., Hanks, S.K. (2018). p130Cas. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_460
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DOI: https://doi.org/10.1007/978-3-319-67199-4_460
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